中国医学创新
中國醫學創新
중국의학창신
MEDICAL INNOVATION OF CHINA
2015年
13期
153-156
,共4页
p38MAPK%糖尿病心肌病%微血管病变%心肌间质纤维化%心肌肥大%心肌凋亡
p38MAPK%糖尿病心肌病%微血管病變%心肌間質纖維化%心肌肥大%心肌凋亡
p38MAPK%당뇨병심기병%미혈관병변%심기간질섬유화%심기비대%심기조망
p38 mitogen-activated protein kinase%Diabetic cardiomyopathy%Microvascular disease%Myocardial fibrosis%Cardiac hypertrophy%Myocardial apoptosis
p38丝裂原活化蛋白激酶（p38 mitogen-activated protein kinase，p38MAPK）是丝裂原活化蛋白激酶（MAPK）信号系统的重要分支，是主要分布于细胞浆的一种丝氨酸/苏氨酸蛋白激酶，它在糖尿病心肌病（diabetic cardiomyopathy，DCM）发病中起重要作用，可被多种因素激活，在微血管病变、心肌间质纤维化、心肌肥厚、心肌凋亡中扮演着重要角色。深入研究p38MAPK在DCM中的分子机制，有助于阐明DCM发病机制，为防治DCM提供新靶点。
p38絲裂原活化蛋白激酶（p38 mitogen-activated protein kinase，p38MAPK）是絲裂原活化蛋白激酶（MAPK）信號繫統的重要分支，是主要分佈于細胞漿的一種絲氨痠/囌氨痠蛋白激酶，它在糖尿病心肌病（diabetic cardiomyopathy，DCM）髮病中起重要作用，可被多種因素激活，在微血管病變、心肌間質纖維化、心肌肥厚、心肌凋亡中扮縯著重要角色。深入研究p38MAPK在DCM中的分子機製，有助于闡明DCM髮病機製，為防治DCM提供新靶點。
p38사렬원활화단백격매（p38 mitogen-activated protein kinase，p38MAPK）시사렬원활화단백격매（MAPK）신호계통적중요분지，시주요분포우세포장적일충사안산/소안산단백격매，타재당뇨병심기병（diabetic cardiomyopathy，DCM）발병중기중요작용，가피다충인소격활，재미혈관병변、심기간질섬유화、심기비후、심기조망중분연착중요각색。심입연구p38MAPK재DCM중적분자궤제，유조우천명DCM발병궤제，위방치DCM제공신파점。
p38 mitogen-activated protein kinase(p38MAPK)is an important member of the mitogen-activated protein kinase(MAPK)superfamily,which is mainly distributed in the cytoplasm and a serine/threonine kinase. It plays an important role in the pathogenesis of diabetic cardiomyopathy(DCM),such as microvascular disease,myocardial fibrosis,cardiac hypertrophy,myocardial apoptosis and so on,which can be activated by a variety of factors. Studying the role of p38MAPK is helpful to further clarify the pathogenesis of DCM,as well as to provide new target for DCM treatment.
