国际外科学杂志
國際外科學雜誌
국제외과학잡지
INTERNATIONAL JOURNAL OF SURGERY
2015年
3期
182-186,封3
,共6页
陈淑明%宋洪涛%陈少全%张敏新%张再重%原博%唐玉娟%王烈
陳淑明%宋洪濤%陳少全%張敏新%張再重%原博%唐玉娟%王烈
진숙명%송홍도%진소전%장민신%장재중%원박%당옥연%왕렬
普萘洛尔%凝胶类%儿童%血管瘤
普萘洛爾%凝膠類%兒童%血管瘤
보내락이%응효류%인동%혈관류
Propranolol%Gels%Child%Hemangioma
目的 评价口服联合外涂普萘洛尔治疗婴幼儿血管瘤的临床疗效.方法 回顾性分析南京军区福州总医院普通外科201 1年6月-2013年12月收治的61例婴幼儿血管瘤患者的临床资料,给予口服联合外涂普萘洛尔治疗,观察其瘤体大小、颜色、质地变化,检测瘤体血流阻力、血流峰值变化,检测血药浓度及不良反应.结果 59例获长期随访,按Achauer分级标准评定疗效:有效率为96.61％(57/59),随着用药时间延长,血管瘤瘤体静脉阻力系数增大,血流峰值减小(P＜0.05),用药1、3、5、7个月的血药浓度分别(166.94 ±40.75) ng/mL、(164.74±42.31) ng/mL、(152.38 ±47.49) ng/mL、(174.51±56.67) ng/mL,差异无统计学意义(P＞0.05).结论 口服联合外涂普萘洛尔治疗婴幼儿血管瘤具有疗效显著、不良反应小的优势.
目的 評價口服聯閤外塗普萘洛爾治療嬰幼兒血管瘤的臨床療效.方法 迴顧性分析南京軍區福州總醫院普通外科201 1年6月-2013年12月收治的61例嬰幼兒血管瘤患者的臨床資料,給予口服聯閤外塗普萘洛爾治療,觀察其瘤體大小、顏色、質地變化,檢測瘤體血流阻力、血流峰值變化,檢測血藥濃度及不良反應.結果 59例穫長期隨訪,按Achauer分級標準評定療效:有效率為96.61％(57/59),隨著用藥時間延長,血管瘤瘤體靜脈阻力繫數增大,血流峰值減小(P＜0.05),用藥1、3、5、7箇月的血藥濃度分彆(166.94 ±40.75) ng/mL、(164.74±42.31) ng/mL、(152.38 ±47.49) ng/mL、(174.51±56.67) ng/mL,差異無統計學意義(P＞0.05).結論 口服聯閤外塗普萘洛爾治療嬰幼兒血管瘤具有療效顯著、不良反應小的優勢.
목적 평개구복연합외도보내락이치료영유인혈관류적림상료효.방법 회고성분석남경군구복주총의원보통외과201 1년6월-2013년12월수치적61례영유인혈관류환자적림상자료,급여구복연합외도보내락이치료,관찰기류체대소、안색、질지변화,검측류체혈류조력、혈류봉치변화,검측혈약농도급불량반응.결과 59례획장기수방,안Achauer분급표준평정료효:유효솔위96.61％(57/59),수착용약시간연장,혈관류류체정맥조력계수증대,혈류봉치감소(P＜0.05),용약1、3、5、7개월적혈약농도분별(166.94 ±40.75) ng/mL、(164.74±42.31) ng/mL、(152.38 ±47.49) ng/mL、(174.51±56.67) ng/mL,차이무통계학의의(P＞0.05).결론 구복연합외도보내락이치료영유인혈관류구유료효현저、불량반응소적우세.
Objective To evaluate the efficacy and security of infantile hemangiomas treatment with oraling propranolol tablets and coating propranolol gel.Methods Study the clinical features and data for 61 infants with hemangiomas who treatment with oral propranolol tablets and coated with of Propranolol gel from June 2011 to December 2013,changes in hemangioma size,texture,color,plasma concentration,tumor peak systolic velocity and resistant index were recorded.Results The results were evaluated using Achauer system:the total effective rate was 96.61％ (57/59).Resistant index increased but Peak Systolic velocity decreased with treatment for a time (P ＜ 0.05),the Plasma concentration is (166.94 ± 40.75) ng/mL,(164.74 ± 42.31) ng/mL,(152.38 ± 47.49)ng/mL,(174.51± 56.67) ng/mL after treatment 1,3,5,7 month,the difference was not statistically significant (P ＞ 0.05).Conclusions Oral propranolol tablets and coated with of Propranolol gel is an effective treatment for infantile hemangiomas.
