CAJ | 학술논문

DNA基因启动子甲基化是重要的表观遗传学机制之一,是导致抑癌基因表达沉默的重要分子生物学基础.乳腺癌患者外周血中循环游离DNA含量明显高于健康人,且具有与肿瘤原发灶一致的基因异常改变.研究显示,乳腺癌患者外周血循环游离DNA中存在多种基因甲基化异常,且与患者的临床病理特征存在不同程度的相关性,在乳腺癌的早期诊断、预后判断、疗效预测和复发监测等方面具有重要价值,本文就循环游离DNA甲基化在乳腺癌中的相关研究进展作一综述.
DNA기인계동자갑기화시중요적표관유전학궤제지일,시도치억암기인표체침묵적중요분자생물학기출.유선암환자외주혈중순배유리DNA함량명현고우건강인,차구유여종류원발조일치적기인이상개변.연구현시,유선암환자외주혈순배유리DNA중존재다충기인갑기화이상,차여환자적림상병리특정존재불동정도적상관성,재유선암적조기진단、예후판단、료효예측화복발감측등방면구유중요개치,본문취순배유리DNA갑기화재유선암중적상관연구진전작일종술.
DNA methylation is one of the most important epigenetic mechanism and molecular biological basis in tumor suppressor gene silencing.It is now well recognized that solid malignant tumors can release a significant amount of genomic DNA into systemic circulation,and with more than 90％ of this total circulating cell-free DNA derived from tumor tissue,which can reflect the overall cell heterogeneity of the tumor itself.In breast cancer,the presence of abnormally high DNA concentrations in plasma has been reported,and changes in the levels of these circulating DNA associated with tumor burden and progression have been confirmed repeatedly.Accumulating data strongly suggested that DNA methylation patterns found in circulating cell free DNA were similarly with the primary tumor,and could be a useful biomarker in early diagnosis,prognosis assessment,and recurrence monitoring for breast cancer patients.Here,we summarize the latest advances in this research field.