中国医学创新
中國醫學創新
중국의학창신
MEDICAL INNOVATION OF CHINA
2015年
13期
26-28
,共3页
脑梗死亚型%胰岛素抵抗%关系
腦梗死亞型%胰島素牴抗%關繫
뇌경사아형%이도소저항%관계
Subtypes of ischemic stroke%Insulin resistancein%Relationship
目的：探讨不同亚型急性脑梗死与胰岛素抵抗关系。方法：选取脑梗死患者101例分为动脉粥样硬化血栓形成组（Atherothrombotic infarction ，AT组）、急性穿支小动脉闭塞组（Acute perforating small artery occlusion，APSAO组）、心源性栓塞组（Cardioembolic infarction，CE组）三组，比较三组患者胰岛素抵抗指数（Homeostasis model assessment for insulin resistance，HOMA-IR）值。结果：AT组中糖代谢异常（abnormal glucose metabolism，AGM）患者HOMA-IR值远远大于CE组AGM患者（P<0.01）。APSAO组HOMA-IR值亦高于CE组（P<0.05）。AT组中AGM患者的HOMA-IR值远远大于正常糖代谢（Normal glucose tolerance，NGT）患者（P<0.01）。APSAO组中AGM患者的HOMA-IR值亦大于NGT患者（P<0.05）。结论：胰岛素抵抗与动脉粥样硬化血栓形成、急性穿支小动脉闭塞脑梗塞均密切相关，对胰岛素抵抗的及早干预在脑梗塞的二级预防中尤其重要。
目的：探討不同亞型急性腦梗死與胰島素牴抗關繫。方法：選取腦梗死患者101例分為動脈粥樣硬化血栓形成組（Atherothrombotic infarction ，AT組）、急性穿支小動脈閉塞組（Acute perforating small artery occlusion，APSAO組）、心源性栓塞組（Cardioembolic infarction，CE組）三組，比較三組患者胰島素牴抗指數（Homeostasis model assessment for insulin resistance，HOMA-IR）值。結果：AT組中糖代謝異常（abnormal glucose metabolism，AGM）患者HOMA-IR值遠遠大于CE組AGM患者（P<0.01）。APSAO組HOMA-IR值亦高于CE組（P<0.05）。AT組中AGM患者的HOMA-IR值遠遠大于正常糖代謝（Normal glucose tolerance，NGT）患者（P<0.01）。APSAO組中AGM患者的HOMA-IR值亦大于NGT患者（P<0.05）。結論：胰島素牴抗與動脈粥樣硬化血栓形成、急性穿支小動脈閉塞腦梗塞均密切相關，對胰島素牴抗的及早榦預在腦梗塞的二級預防中尤其重要。
목적：탐토불동아형급성뇌경사여이도소저항관계。방법：선취뇌경사환자101례분위동맥죽양경화혈전형성조（Atherothrombotic infarction ，AT조）、급성천지소동맥폐새조（Acute perforating small artery occlusion，APSAO조）、심원성전새조（Cardioembolic infarction，CE조）삼조，비교삼조환자이도소저항지수（Homeostasis model assessment for insulin resistance，HOMA-IR）치。결과：AT조중당대사이상（abnormal glucose metabolism，AGM）환자HOMA-IR치원원대우CE조AGM환자（P<0.01）。APSAO조HOMA-IR치역고우CE조（P<0.05）。AT조중AGM환자적HOMA-IR치원원대우정상당대사（Normal glucose tolerance，NGT）환자（P<0.01）。APSAO조중AGM환자적HOMA-IR치역대우NGT환자（P<0.05）。결론：이도소저항여동맥죽양경화혈전형성、급성천지소동맥폐새뇌경새균밀절상관，대이도소저항적급조간예재뇌경새적이급예방중우기중요。
Objective:To assess the relationship between subtypes of ischemic stroke and insulin resistance. Method:101 enrolled patients diagnosed with cerebral infarction were divided into 3 groups,atherothrombotic infarction group(AT group );acute perforating small artery occlusion group(APSAO group)and cardioembolic infarction group(CE group).We investigated the relationships between ischemic stroke subtypes and the prevalence of insulin resistance used by homeostasis model assessment for insulin resistance(HOMA-IR).Result:The mean of HOMA-IR was significantly increase in the AT group with AGM compared to the CE group,the difference was statistically significant (P<0.01).The mean of HOMA-IR was also higher in the APSAO group with AGM than the CE group,the difference was statistically significant(P<0.05). The mean of HOMA-IR was significantly increase in the AT group with AGM compared to the NGT,the difference was statistically significant(P<0.01). The mean of HOMA-IR was also higher in the APSAO group with AGM than the NGT,the difference was statistically significant(P<0.05).Conclusion:insulin resistance is not only associated closely with atherothrombotic infarction,but also has a close relationship with acute perforating small artery occlusion infarction.Early intervention and treatment for insulin resistance seems to be important for the secondary prevention of ischemic stroke.
