CAJ | 학술논문

目的：探讨黄芩苦参合剂雾化吸入对化疗后下呼吸道院内感染患者并发侵袭性肺部真菌感染的预防作用。方法选择60例肿瘤化疗后下呼吸道院内感染老年患者，随机分为对照组及治疗组，每组30例，所有患者均依据药敏结果抗感染治疗，治疗组患者另给予黄芩苦参合剂雾化吸入每日2次，2周后比较两组患者临床治疗效果，观察两组肺部真菌感染发生率及发生时间，比较两组患者治疗前后血气分析情况。结果治疗组临床有效率86.67%，对照组临床有效率70.00%，治疗组临床有效率高于对照组；治疗组肺部真菌感染率6.67%，对照组肺部真菌感染率23.33%，治疗组真菌感染率低于对照组；治疗组真菌感染时间(11.58±1.3)d，对照组真菌感染时间(9.41±1.10)d，治疗组真菌感染时间迟于对照组；两组患者治疗前血气分析pH、SaO2、PaCO2、PaO2水平无显著差异，治疗2周后治疗组pH、SaO2、PaO2水平高于对照组，PaCO2水平低于对照组。结论黄芩苦参合剂雾化吸入能够改善化疗后下呼吸道院感老年患者的临床疗效，改善呼吸功能，预防继发侵袭性肺部真菌感染，具有较好的临床效果。
목적：탐토황금고삼합제무화흡입대화료후하호흡도원내감염환자병발침습성폐부진균감염적예방작용。방법선택60례종류화료후하호흡도원내감염노년환자，수궤분위대조조급치료조，매조30례，소유환자균의거약민결과항감염치료，치료조환자령급여황금고삼합제무화흡입매일2차，2주후비교량조환자림상치료효과，관찰량조폐부진균감염발생솔급발생시간，비교량조환자치료전후혈기분석정황。결과치료조림상유효솔86.67%，대조조림상유효솔70.00%，치료조림상유효솔고우대조조；치료조폐부진균감염솔6.67%，대조조폐부진균감염솔23.33%，치료조진균감염솔저우대조조；치료조진균감염시간(11.58±1.3)d，대조조진균감염시간(9.41±1.10)d，치료조진균감염시간지우대조조；량조환자치료전혈기분석pH、SaO2、PaCO2、PaO2수평무현저차이，치료2주후치료조pH、SaO2、PaO2수평고우대조조，PaCO2수평저우대조조。결론황금고삼합제무화흡입능구개선화료후하호흡도원감노년환자적림상료효，개선호흡공능，예방계발침습성폐부진균감염，구유교호적림상효과。
[Abstratct] Objective To investigate the preventive effect of atomization inhalation with mixture of baikal skullcap root and light yellow sophora root for proventing invasive fungal infection on lower respiratory tract infection after chemotherapy. Methods A total of 60 cases of patients with lower respiratory tract infections after chemotherapy were selected and randomized into control groups and treatment groups, there were 30 cases in every group, anti-infection was taken in two groups according to drug sensitivity test,atomamdation inhalation with mixture of baikal skullcap root and light yellow sophora root was taken in treatment groups in addition, clinical effect was contrasted, incidence rate and time of fungal infection were contrasted between control group and treatment group,and index of blood gas analysis was contrasted between control group and treatment group after two weeks. Results Clinical efficiency was 86.67% in treatment group and was 70.00% in control group,clinical efficiency was higher in treatment groups than in control group,incidence rate of fungal infection was 6.67% in treatment group and was 23.33% in control group,incidence rate of fungal infection was lower in treatment group than in control goup,time of fungal infection was (11.58±1.31)days in treatment group and was (9.41±1.10)days in control group,time of fungal infect was later in treatment group than that in control group. There were no significant differences of the levels of pH,SaO2,PaCO2 and PaO2 between the two groups before treatment, the levels of pH,SaO2,and PaO2 were higher and PaCO2 was lower in treatment group than that in control goup after treatment. Conclusion Atomization inhalation with mixture of baikal skullcap root and light yellow sophora root could improve clinical curative effect of lower respiratory tract infection after chemotherapy,and im-prove respiratory function,provent invasive fungal infections and has good clinical effect.