CAJ | 학술논문

目的：探讨Logistic回归和ROC曲线综合分析血清癌胚抗原（CEA）、鳞状细胞癌抗原（SCC）和铁蛋白（SF）检测在肺癌淋巴结转移中的应用价值。方法：采用电化学发光法检测CEA，酶免法检测SCC，免疫比浊法检测SF，检测100例肺癌患者血清中三种肿瘤标志物水平，其中转移组65例，未转移组35例。结果：转移组CEA、SCC的阳性率显著高于未转移组的阳性率（P<0.01，P<0.05），而SF在两组间的阳性率比较差异无统计学意义。建立回归模型Y=1/[1+EXP（1.584X1+0.935X2-0.425）]，新变量Y的AUC高于3种单一肿瘤标志物的AUC。结论：CEA和SCC对肺癌淋巴结转移的诊断具有较高的价值，综合运用Logistic回归和ROC曲线分析的提高临床判断肺癌淋巴结转移的准确性。
목적：탐토Logistic회귀화ROC곡선종합분석혈청암배항원（CEA）、린상세포암항원（SCC）화철단백（SF）검측재폐암림파결전이중적응용개치。방법：채용전화학발광법검측CEA，매면법검측SCC，면역비탁법검측SF，검측100례폐암환자혈청중삼충종류표지물수평，기중전이조65례，미전이조35례。결과：전이조CEA、SCC적양성솔현저고우미전이조적양성솔（P<0.01，P<0.05），이SF재량조간적양성솔비교차이무통계학의의。건립회귀모형Y=1/[1+EXP（1.584X1+0.935X2-0.425）]，신변량Y적AUC고우3충단일종류표지물적AUC。결론：CEA화SCC대폐암림파결전이적진단구유교고적개치，종합운용Logistic회귀화ROC곡선분석적제고림상판단폐암림파결전이적준학성。
Objective:To investigate the diagnostic value of serum CEA,SCC and SF as analyzed with Logistic vegression and ROC curve in patients with lung cancer lymph nodes metastasis. Method:Serum CEA,SCC,and SF were detected in 100 patients with lung cancer,and in those cases,65 cases were identified as lymph nodes metastasis group and 35 as non-metsatasis group. Result:The positive rate of CEA and SCC of metastais group was evidently higher than that of non-metastasis(P<0.01,P<0.05),but there was no significant difference for SF between the two groups. According to regression equation Y=1/[1+EXP(1.584X1+0.935X2-0.425)],and the AUC of variable Y was higher than any of the three tumor markers. Conclusion:The combination of CEA and SCC is useful as indicator of lung cancer lymph nodes metastasis. Applications of Logistic regression and ROC curve increase diagnostic accuracy in lung cancer.