CAJ | 학술논문

目的：利用Meta分析的方法对国内发表文献中的流行性感冒（流感）发病情况进行系统的分析，找出国内近几年流感发病情况的规律和特点，为流感病毒防治提供参考。方法从中国知网CNKI等中收集到2005年至2012年发表的符合纳入标准的文献，利用Review Manager 5．0软件对流感发病情况进行Meta分析。结果共筛选出22篇文献，流感样病例（ ILI）样本量总数达957901例，病原检测数样本量达148233份。流感样病例方面，0～4岁婴幼儿组与15～59岁组无差别，与60岁以上老年人组有较大差别；60岁以上老年人组与15～59岁组也存在较大差异。病原学方面，各年龄段之间以25～59岁组流感病毒检出率最高；2009年病毒检出数较其他年份多（合并OR：2．17，95％CI：1．27～3．70），甲型H1N1流感病毒检出数较甲型季节性流感病毒有统计学差别（OR：2．25，95％CI：1．30～3．91）；甲型流感病毒与乙型流感病毒相比差异有统计学意义（ OR：4．05，95％CI：2．53～6．47）。结论两个年龄段（0～4岁、≥60岁）在ILI确诊率存在较大差异，应加强对这两组流感病毒感染的高危人群的防控；25～59岁人群流动性大、接触面广，应加强防控；新型甲型H1N1病毒暴发的2009年，流感病毒检出率较其他年份多；甲型流感H1N1病毒暴发后，其检出率是季节性甲型流感的2．25倍，要加强对新型甲型流感或者暴发流行流感病毒的防控；甲型流感病毒的检出率是乙型流感病毒检出率的4．05倍，应加强对甲型流感的防控。
목적：이용Meta분석적방법대국내발표문헌중적류행성감모（류감）발병정황진행계통적분석，조출국내근궤년류감발병정황적규률화특점，위류감병독방치제공삼고。방법종중국지망CNKI등중수집도2005년지2012년발표적부합납입표준적문헌，이용Review Manager 5．0연건대류감발병정황진행Meta분석。결과공사선출22편문헌，류감양병례（ ILI）양본량총수체957901례，병원검측수양본량체148233빈。류감양병례방면，0～4세영유인조여15～59세조무차별，여60세이상노년인조유교대차별；60세이상노년인조여15～59세조야존재교대차이。병원학방면，각년령단지간이25～59세조류감병독검출솔최고；2009년병독검출수교기타년빈다（합병OR：2．17，95％CI：1．27～3．70），갑형H1N1류감병독검출수교갑형계절성류감병독유통계학차별（OR：2．25，95％CI：1．30～3．91）；갑형류감병독여을형류감병독상비차이유통계학의의（ OR：4．05，95％CI：2．53～6．47）。결론량개년령단（0～4세、≥60세）재ILI학진솔존재교대차이，응가강대저량조류감병독감염적고위인군적방공；25～59세인군류동성대、접촉면엄，응가강방공；신형갑형H1N1병독폭발적2009년，류감병독검출솔교기타년빈다；갑형류감H1N1병독폭발후，기검출솔시계절성갑형류감적2．25배，요가강대신형갑형류감혹자폭발류행류감병독적방공；갑형류감병독적검출솔시을형류감병독검출솔적4．05배，응가강대갑형류감적방공。
Objective To investigate the epidemic patterns and the characteristics of influenza in Chi-na through a Meta-analysis based on the studies published in domestic literatures.Methods Related articles published during 2005 to 2012 were screened out from domestic databases and analyzed through a Meta-analysis with Review Manager 5.0 software.Results Twenty-two articles covering 957 901 patients with influenza-like-illness (ILI) and 148 233 pathogen samples were screened out according to the inclusion criteria.No significant difference with the ILI diagnosis rate was found between subjects at age 0-4 years and those at age 15-59 years. Higher ILI diagnosis rates were observed in those two groups as compared with subjects elder than 60 years old. Most of the pathogen samples were carried by subjects aged 25-59 years.More influenza virus strains were isola-ted in 2009 as compared with those of the seven other years (OR=2.25, 95%CI=1.27-3.70).There was sta-tistical difference between the numbers of influenza A H1N1 and seasonal influenza A strains (OR=2.25, 95%CI=1.30-3.91) .Significant difference was also observed between the numbers of influenza A and influenza B strains (OR=4.05, 95%CI=2.53-6.47).Conclusion There was significant difference with the diagnosis rate between subjects aged 0-4 years and those aged≥60 years.More attention should be paid to people at high risk of infection (0-4 years old and≥60 years old) and those at 25-29 years with high mobility and social inter-course for the timely prevention and control of pandemic influenza.The detection rate of influenza virus strains was increased during the outbreak of novel influenza A H1N1 infection in 2009.After that outbreak, the detec-tion rate of novel influenza A H1N1 strains was 2.25 times the rate of seasonal influenza strains.The detection rate of influenza A was 4.05 times the rate of influenza B virus strains.Therefore, it is necessary to strengthen the surveillance for influenza A virus and other epidemic influenza virus strains.