CAJ | 학술논문

本文综述呼吸道病毒感染在婴幼儿毛细支气管炎、支气管哮喘(简称哮喘)等喘息性疾病中的作用,及病毒感染对哮喘和变态反应性疾病的影响.呼吸道病毒感染可以损伤气道上皮,直接激活末梢神经,导致气道细胞产生多种炎性细胞因子及趋化因子,导致喘息、咳嗽等临床症状的产生,同时影响机体免疫功能,导致免疫功能紊乱.呼吸道病毒感染对喘息及哮喘患儿的影响是急性损害和长期作用并存,特应性体质的患儿对病毒感染更加敏感.有效地控制婴幼儿时期的呼吸道病毒性感染,可以减少喘息性疾病的发作,并最终减少哮喘的发生.
본문종술호흡도병독감염재영유인모세지기관염、지기관효천(간칭효천)등천식성질병중적작용,급병독감염대효천화변태반응성질병적영향.호흡도병독감염가이손상기도상피,직접격활말소신경,도치기도세포산생다충염성세포인자급추화인자,도치천식、해수등림상증상적산생,동시영향궤체면역공능,도치면역공능문란.호흡도병독감염대천식급효천환인적영향시급성손해화장기작용병존,특응성체질적환인대병독감염경가민감.유효지공제영유인시기적호흡도병독성감염,가이감소천식성질병적발작,병최종감소효천적발생.
This paper aims to summarize the function of respiratory virus infection in asthmatic diseases suffered by infants and children,such as capillary bronchitis and bronchial asthma (asthma),and the effect of virus infection in asthma and allergic diseases.Respiratory virus infection will injure airway epithelium and activate peripheral nerve,leading air passage cells to produce various inflammatory cytokines and chemokines,and resulting in clinical symptoms of wheezing and coughing;meanwhile,it will affect the body immunity,leading to immune dysfunction.The effect of respiratory virus infection in infant and children patients suffering wheeze and asthma is characteristic of a combination of acute injury and long-term effect.Infant and children patients with habitus of atopy will be more sensitive to virus infection.Effectively controlling respiratory virus infections in infancy can reduce the possibility of asthmatic diseases attack,thus reducing the possibility of asthma attack.