CAJ | 학술논문

COPD是一种以气流受限和慢性气道炎症为特征的呼吸道疾病.高迁移率族蛋白1(H MGB1)是存在于真核细胞核内的非组蛋白染色体结合蛋白,其释放到细胞外参与介导自身免疫性疾病.其作为一种重要的报警素分子,已被证明在肺部慢性炎症的发病机制中扮演重要角色,HMGB1在COPD的发生、发展过程中可能存在重要作用,本文就HMGB1与COPD的关系作一综述.
COPD시일충이기류수한화만성기도염증위특정적호흡도질병.고천이솔족단백1(H MGB1)시존재우진핵세포핵내적비조단백염색체결합단백,기석방도세포외삼여개도자신면역성질병.기작위일충중요적보경소분자,이피증명재폐부만성염증적발병궤제중분연중요각색,HMGB1재COPD적발생、발전과정중가능존재중요작용,본문취HMGB1여COPD적관계작일종술.
Chronic obstructive pulmonary disease (COPD) is characterised by progressive airflow limitation that is not fully reversible.It is associated with an abnormal inflammatory response of the lung,which results in airway obstruction,destruction of parenchyma and development of emphysema.Highmobility group box 1 (HMGB1) is a non-histone nuclear protein that is released extracellulary and has implicated in autoimmune disease.It is characterized as alarmin and had proved to be implicated into the pathogenesis of COPD.The main problems discussed in this review makes a retrospective exposition on the research progress about the correlation between HMGB1 and COPD.