CAJ | 학술논문

目的：探讨类风湿关节炎(RA)患者中血浆D-二聚体(D-D)水平变化，并分析其与各临床指标的关系。方法检测138例RA患者和47例正常对照组患者血浆D-二聚体水平，分析其与年龄、类风湿因子(RF)、红细胞沉降率(ESR)、视觉模拟评分(VAS评分)、血小板的相关性。结果 RA组血浆D-二聚体水平明显高于健康对照组，差异有统计学意义(P<0.01)；病情高活动组、病情低活动组RA患者D-二聚体水平明显高于病情缓解组RA患者(P均<0.01)；病情高活动组RA患者D-二聚体水平明显高于病情低活动组(P<0.01)；所有RA患者D-二聚体水平与年龄、ESR、VAS评分、RF、血小板均呈明显正相关(P均<0.01)。结论 RA患者体内存在高凝状态，D-二聚体可作为临床判断RA患者病情活动的非特异性炎性反应指标，亦可指导临床治疗。
목적：탐토류풍습관절염(RA)환자중혈장D-이취체(D-D)수평변화，병분석기여각림상지표적관계。방법검측138례RA환자화47례정상대조조환자혈장D-이취체수평，분석기여년령、류풍습인자(RF)、홍세포침강솔(ESR)、시각모의평분(VAS평분)、혈소판적상관성。결과 RA조혈장D-이취체수평명현고우건강대조조，차이유통계학의의(P<0.01)；병정고활동조、병정저활동조RA환자D-이취체수평명현고우병정완해조RA환자(P균<0.01)；병정고활동조RA환자D-이취체수평명현고우병정저활동조(P<0.01)；소유RA환자D-이취체수평여년령、ESR、VAS평분、RF、혈소판균정명현정상관(P균<0.01)。결론 RA환자체내존재고응상태，D-이취체가작위림상판단RA환자병정활동적비특이성염성반응지표，역가지도림상치료。
Objective To study the plasma D-dimer (DD) level changes in the patients with rheumatoid arthritis (RA), and to analyze its correlation with various clinical indicators. Methods Selected a total of 138 cases of RA patients and 50 cases of normal person as matched group the plasma D-dimer level and the correlation analysis with age, rheuma-toid factor (RF), erythrocyte sedimentation rate (ESR), visual analogue scale (VAS score)and platelet were analyzed. Results The level of D-dimer level in RA patients was significantly higher than that of healthy controls, and the dif-ference was statistically significant (P<0.01);The D-dimer level of high disease activity group and low disease activity group with RA patients were significantly higher than the remission groups of RA patients (P all <0.01); The D-dimer level in high disease activity group of RA patients was significantly higher than the low disease activity group (P<0.01); There were positive correlations between the D-dimer level and the age, ESR, VAS score, RF, platelet in all RA patients (P all <0.01). Conclusion There is high coagulation state in RA patients, so the D-dimer can be used as a clinical nonspecific inflammatory reaction index in patients with RA, and can direct the clinical treatment.