CAJ | 학술논문

使用抗癫(癎)药物治疗的癫(癎)患者中,大约1/3癫(癎)发作不能得到有效控制,表现为对抗癫(癎)药物耐药.耐药性产生的机制目前考虑可能是多种因素共同作用所致.耐药性癫(癎)与难治性癫(癎)2个概念语义及内涵存在区别.自2010年国际抗癫(癎)联盟提出“耐药性癫(癎)”定义的专家共识以来,不同医疗中心应用新定义标准针对不同人群进行研究,证实新定义的有效性和可靠性较好,同时对于定义中药物剂量、药物种类、评判时间、治疗结果判定等评价指标的设定存在争议.
사용항전(간)약물치료적전(간)환자중,대약1/3전(간)발작불능득도유효공제,표현위대항전(간)약물내약.내약성산생적궤제목전고필가능시다충인소공동작용소치.내약성전(간)여난치성전(간)2개개념어의급내함존재구별.자2010년국제항전(간)련맹제출“내약성전(간)”정의적전가공식이래,불동의료중심응용신정의표준침대불동인군진행연구,증실신정의적유효성화가고성교호,동시대우정의중약물제량、약물충류、평판시간、치료결과판정등평개지표적설정존재쟁의.
In the use of antiepileptic drugs in patients with epilepsy,1/3 of the patients with epilepsy can not get effective control,showing resistance to antiepileptic drugs.Now the mechanism of drug resistance is considered to be caused by multiple factors work together.The concept and connotation between drug-resistant epilepsy and refractory epilepsy are different.Since 2010,the international union of antiepileptic proposed " drug-resistant epilepsy" expert consensus,different medical centers use the new defition to study different populations and confirm that the new definition is effective and reliable.However,there are some controversier about the drug dosage,drug kinds,judge for determining evaluation index and the treatment judgement in that definition.