国际医药卫生导报
國際醫藥衛生導報
국제의약위생도보
INTERNATIONAL MEDICINE & HEALTH GUIDANCE NEWS
2015年
10期
1337-1340
,共4页
周智美%陈德基%王延平%黄勇
週智美%陳德基%王延平%黃勇
주지미%진덕기%왕연평%황용
阿尔茨海默病%磁共振成像%扩散张量成像%脑白质
阿爾茨海默病%磁共振成像%擴散張量成像%腦白質
아이자해묵병%자공진성상%확산장량성상%뇌백질
Alzheimer's disease%Magnetic resonance imaging%Diffusion tensor imaging%White matter
目的 应用磁共振DTI技术对阿尔茨海默病(Alzheimer's disease,AD)早期患者的脑白质进行研究,探讨AD早期脑白质的DTI改变.方法 选取AD早期患者和对照组各35例进行DTI序列扫描,通过设置脑白质感兴趣区,测量两组的MD、FA值并作统计分析.结果 AD组的MD值较对照组增高,在穹隆、左侧颞叶有统计学差异;AD组的FA值较对照组减低,在穹隆、左侧颞叶有统计学差异.结论 穹隆和左侧颞叶是AD早期DTI检查的敏感结构,可反映AD早期脑白质微观结构的变化.
目的 應用磁共振DTI技術對阿爾茨海默病(Alzheimer's disease,AD)早期患者的腦白質進行研究,探討AD早期腦白質的DTI改變.方法 選取AD早期患者和對照組各35例進行DTI序列掃描,通過設置腦白質感興趣區,測量兩組的MD、FA值併作統計分析.結果 AD組的MD值較對照組增高,在穹隆、左側顳葉有統計學差異;AD組的FA值較對照組減低,在穹隆、左側顳葉有統計學差異.結論 穹隆和左側顳葉是AD早期DTI檢查的敏感結構,可反映AD早期腦白質微觀結構的變化.
목적 응용자공진DTI기술대아이자해묵병(Alzheimer's disease,AD)조기환자적뇌백질진행연구,탐토AD조기뇌백질적DTI개변.방법 선취AD조기환자화대조조각35례진행DTI서렬소묘,통과설치뇌백질감흥취구,측량량조적MD、FA치병작통계분석.결과 AD조적MD치교대조조증고,재궁륭、좌측섭협유통계학차이;AD조적FA치교대조조감저,재궁륭、좌측섭협유통계학차이.결론 궁륭화좌측섭협시AD조기DTI검사적민감결구,가반영AD조기뇌백질미관결구적변화.
Objective To investigate DTI appearance of early Alzheimer's disease (AD)patients' white matter changes.Methods 35 early AD patients and 35 volunteers were enrolled and examined with DTI scanning.MD and FA were acquired by setting regions of interest.Results MD value of AD group raised mostly,with statistically significant differences in fomix,left temporal lobe between two groups.FA value of AD group reduced mostly,with statistically significant differences in fornix,left temporal lobe between two groups.Conclusions Fornix and left temporal lobe were sensitive organizations for early AD with DTI scan,they were associated with micro-structural changes of white matter in early AD.
