CAJ | 학술논문

在皮肤科治疗中,局部用药应用广泛,如何提高传统局部经皮给药的生物利用度具有重要的应用价值.近年来研究发现,激光可以促进药物透过皮肤,不仅提高药物吸收率,也增加其渗透深度.传统剥脱激光作用效果显著,但其不良反应如红斑、疼痛等发生率较高.点阵激光的出现,突破传统激光的局限,其局灶性光热作用的原理,提高药物透皮作用的同时降低光热损伤,显示出较强的临床应用优势.
재피부과치료중,국부용약응용엄범,여하제고전통국부경피급약적생물이용도구유중요적응용개치.근년래연구발현,격광가이촉진약물투과피부,불부제고약물흡수솔,야증가기삼투심도.전통박탈격광작용효과현저,단기불량반응여홍반、동통등발생솔교고.점진격광적출현,돌파전통격광적국한,기국조성광열작용적원리,제고약물투피작용적동시강저광열손상,현시출교강적림상응용우세.
Topical drugs have been widely applied to the treatment of dermatoses,and improving the bioavailability of drugs delivered via traditional transdermal routes is of great value.Recent studies have found that lasers can promote drugs to penetrate the skin with an increase in drug absorbility and penetration depth.Although traditional ablative lasers have remarkable therapeutic effect,there is a high incidence of adverse reactions such as erythema and pain.Based on the theory of selective photothermolysis,fractional lasers can improve skin permeability of drugs with reduced photothermal damage,have broken through the limitations of traditional lasers and shown great potential in clinical application.