国际皮肤性病学杂志
國際皮膚性病學雜誌
국제피부성병학잡지
INTERNATIONAL JOURNAL OF DERMATOLOGY AND VENEREOLOGY
2015年
3期
188-191
,共4页
T淋巴细胞,调节性%B淋巴细胞%免疫调节%皮肤疾病%银屑病%类天疱疮,大疱性
T淋巴細胞,調節性%B淋巴細胞%免疫調節%皮膚疾病%銀屑病%類天皰瘡,大皰性
T림파세포,조절성%B림파세포%면역조절%피부질병%은설병%류천포창,대포성
T-lymphocytes,regulatory%B-lymphocytes%Immunomodulation%Skin diseases%Psoriasis%Pemphigoid,bullous
调节性T细胞在系统性红斑狼疮、银屑病、自身免疫性大疱病等疾病的发病机制中研究很多,随着在人体内发现分泌白细胞介素10的调节性B细胞,人们发现分泌白细胞介素10的调节性B细胞和其分泌的白细胞介素10有负向免疫调节作用,对疾病有保护作用.许多研究表明,在这些疾病中,分泌白细胞介素10的调节性B细胞的数量、功能和其分泌的白细胞介素10水平存在异常,认为这些异常与疾病的发病和病情有关.
調節性T細胞在繫統性紅斑狼瘡、銀屑病、自身免疫性大皰病等疾病的髮病機製中研究很多,隨著在人體內髮現分泌白細胞介素10的調節性B細胞,人們髮現分泌白細胞介素10的調節性B細胞和其分泌的白細胞介素10有負嚮免疫調節作用,對疾病有保護作用.許多研究錶明,在這些疾病中,分泌白細胞介素10的調節性B細胞的數量、功能和其分泌的白細胞介素10水平存在異常,認為這些異常與疾病的髮病和病情有關.
조절성T세포재계통성홍반랑창、은설병、자신면역성대포병등질병적발병궤제중연구흔다,수착재인체내발현분비백세포개소10적조절성B세포,인문발현분비백세포개소10적조절성B세포화기분비적백세포개소10유부향면역조절작용,대질병유보호작용.허다연구표명,재저사질병중,분비백세포개소10적조절성B세포적수량、공능화기분비적백세포개소10수평존재이상,인위저사이상여질병적발병화병정유관.
There have been many researches on the roles of regulatory T cells in the pathogenesis of systemic lupus erythematosus,psoriasis,autoimmune bullous diseases,etc.With the discovery of regulatory B cells secreting interleukin 10 (IL-10),namely B10 cells,in human body,it has been revealed that B10 cells and IL-10 have negative immunoregulatory effect,and can protect against diseases.Many studies have shown that the number and function of B10 cells as well as the level of IL-10 are abnormal in the above diseases,suggesting a relationship between these abnormalities and occurrence as well as development of these diseases.
