国际皮肤性病学杂志
國際皮膚性病學雜誌
국제피부성병학잡지
INTERNATIONAL JOURNAL OF DERMATOLOGY AND VENEREOLOGY
2015年
3期
196-198
,共3页
内源性大麻酚类%受体,大麻酚%皮肤疾病%镇痛%免疫调节%瘙痒症
內源性大痳酚類%受體,大痳酚%皮膚疾病%鎮痛%免疫調節%瘙癢癥
내원성대마분류%수체,대마분%피부질병%진통%면역조절%소양증
Endocannabinoids%Receptors,cannabinoid%Skin diseases%Analgesia%Immunomodulation%Pruritus
内源性大麻素系统在人体有广泛的生理学作用,与镇痛、免疫调节、能量代谢等有关,并在调节瘙痒中起重要作用,影响瘙痒的发生与发展.内源性大麻素受体为G蛋白耦联受体,具有保护神经、抗炎、抑制肿瘤细胞生长等作用.随着研究的深入,发现内源性大麻素系统参与皮肤细胞存活、增殖和分化的调控,是维持皮肤稳态的关键因素.越来越多的研究表明,内源性大麻素系统与众多皮肤病的发生发展密切相关,靶向调控内源性大麻素系统可能有益于相关皮肤病的治疗.
內源性大痳素繫統在人體有廣汎的生理學作用,與鎮痛、免疫調節、能量代謝等有關,併在調節瘙癢中起重要作用,影響瘙癢的髮生與髮展.內源性大痳素受體為G蛋白耦聯受體,具有保護神經、抗炎、抑製腫瘤細胞生長等作用.隨著研究的深入,髮現內源性大痳素繫統參與皮膚細胞存活、增殖和分化的調控,是維持皮膚穩態的關鍵因素.越來越多的研究錶明,內源性大痳素繫統與衆多皮膚病的髮生髮展密切相關,靶嚮調控內源性大痳素繫統可能有益于相關皮膚病的治療.
내원성대마소계통재인체유엄범적생이학작용,여진통、면역조절、능량대사등유관,병재조절소양중기중요작용,영향소양적발생여발전.내원성대마소수체위G단백우련수체,구유보호신경、항염、억제종류세포생장등작용.수착연구적심입,발현내원성대마소계통삼여피부세포존활、증식화분화적조공,시유지피부은태적관건인소.월래월다적연구표명,내원성대마소계통여음다피부병적발생발전밀절상관,파향조공내원성대마소계통가능유익우상관피부병적치료.
Endocannabinoid system has a broad spectrum of physiological effects in human body,is associated with analgesia,immune regulation and energy metabolism,plays an important role in the regulation of pruritus,and affects the occurrence and development of pruritus.Endocannabinoid receptors,a kind of G protein-coupled receptor,can protect nerves,counteract inflammation and inhibit tumor cell growth.Recent research has found that the endocannabinoid system is involved in the regulation of survival,proliferation and differentiation of skin cells,and is a key factor for maintaining skin homeostasis.More and more studies have also demonstrated that the endocannabinoid system is closely related to the occurrence and development of numerous dermatoses,and targeted regulation of the system may benefit the treatment of related dermatoses.
