CAJ | 학술논문

1998年建立基于梅毒螺旋体tpr和arp基因分子分型系统,世界各国均有梅毒螺旋体亚型菌株流行特征的报道并结合tp0548或rpsA基因以加强分型,发现了各地的优势亚型菌株及亚型菌株存在多样性,其中14d和14f是出现频率较高的亚型.另外,某些特定亚型与临床表现之间存在相关性.有研究发现,某些特定亚型菌株可能有亲神经现象,其中14a、14d/f、19d/c与神经梅毒相关.确定特定亚型菌株与神经梅毒的相关性对临床诊治和判断梅毒患者预后意义重大.
1998년건립기우매독라선체tpr화arp기인분자분형계통,세계각국균유매독라선체아형균주류행특정적보도병결합tp0548혹rpsA기인이가강분형,발현료각지적우세아형균주급아형균주존재다양성,기중14d화14f시출현빈솔교고적아형.령외,모사특정아형여림상표현지간존재상관성.유연구발현,모사특정아형균주가능유친신경현상,기중14a、14d/f、19d/c여신경매독상관.학정특정아형균주여신경매독적상관성대림상진치화판단매독환자예후의의중대.
Since the development of molecular typing system for Treponema pallidum based on acidic repeat protein (arp) gene and Treponema pallidum repeat (tpr) gene in 1998,there have been reports on the epidemiological characteristics of Treponema pallidum subtypes from various countries in the world.The tp0548 and rpsA genes also have been used for enhancing the molecular typing of Treponema pallidum.Predominant subtypes of Treponema pallidum have been reported in various regions,and there is a high variety in the subtypes of Treponema pallidum,with 14d and 14f as the most frequent subtypes.Further more,some specific subtypes of Treponema pallidum are associated with clinical manifestations of syphilis.Studies have found that some neurotropic subtypes of Treponema pallidum,for example,14a,14d/f and 19d/c types are related to neurosyphilis.Determining specific Treponema pallidum subtypes associated with neurosyphilis is of great significance for the clinical diagnosis,treatment and prediction of prognosis of syphilis.