长春理工大学学报(自然科学版)
長春理工大學學報(自然科學版)
장춘리공대학학보(자연과학판)
JOURNAL OF CHANGCHUN UNIVERSITY OF SCIENCE AND TECHNOLOGY(NATURAL SCIENCE EDITION)
2015年
2期
90-94
,共5页
两亲性%梳型聚合物%合成%胶束
兩親性%梳型聚閤物%閤成%膠束
량친성%소형취합물%합성%효속
amphiphilic%comb-like block polymer%synthesis%micelle
以端氨基功能化的聚乙二醇单甲醚为引发剂,引发γ-炔丙基-L-谷氨酸-N-羧基内酸酐(PLG-NCA)开环聚合反应,获得聚氨基酸聚乙二醇两亲性嵌段共聚物。并以此为基础,用click方法合成带有二硫键标记的还原敏感性的可降解两亲性梳型嵌段聚合物。最后所得的这种聚合物在水溶液中自主装形成可降解的两亲性的敏感性胶束。这种带有敏感性的胶束可以用于抗癌药物的包覆以及运输和适时的释放;这种胶束具有更高的稳定性和更高的药物释放性。实验采用盐酸阿霉素作为包裹药物,在1/15mol pH=7.4的PBS溶液中进行自主装包裹药物。
以耑氨基功能化的聚乙二醇單甲醚為引髮劑,引髮γ-炔丙基-L-穀氨痠-N-羧基內痠酐(PLG-NCA)開環聚閤反應,穫得聚氨基痠聚乙二醇兩親性嵌段共聚物。併以此為基礎,用click方法閤成帶有二硫鍵標記的還原敏感性的可降解兩親性梳型嵌段聚閤物。最後所得的這種聚閤物在水溶液中自主裝形成可降解的兩親性的敏感性膠束。這種帶有敏感性的膠束可以用于抗癌藥物的包覆以及運輸和適時的釋放;這種膠束具有更高的穩定性和更高的藥物釋放性。實驗採用鹽痠阿黴素作為包裹藥物,在1/15mol pH=7.4的PBS溶液中進行自主裝包裹藥物。
이단안기공능화적취을이순단갑미위인발제,인발γ-결병기-L-곡안산-N-최기내산항(PLG-NCA)개배취합반응,획득취안기산취을이순량친성감단공취물。병이차위기출,용click방법합성대유이류건표기적환원민감성적가강해량친성소형감단취합물。최후소득적저충취합물재수용액중자주장형성가강해적량친성적민감성효속。저충대유민감성적효속가이용우항암약물적포복이급운수화괄시적석방;저충효속구유경고적은정성화경고적약물석방성。실험채용염산아매소작위포과약물,재1/15mol pH=7.4적PBS용액중진행자주장포과약물。
As an initiator with alkoxyamino polyethylene glycol, we trigger the ring opening polymerization forγ-propargyl -L- carboxy glutamic -N- within anhydride (PLG-NCA) to obtain amphiphilic block copolymer. Based on these steps,we use click method to synthesize disulfide-labeled stimuli-responsive degradation comb-like block copoly-mer. At last, the generated polymer generates degradable and amphipathic micelles with sensitivity by self-assemble. These micelles with sensitivity are used to package,transport and release the cancer drugs. These micelles also have a higher stability and a better drug release. The experiment adopts doxorubicin hydrochloride as the wrapping drug by self-assemble in the solution of PBS of 1/15mol Ph=7.4.