CAJ | 학술논문

目的：评价伯氨喹与蒿甲醚联合治疗恶性疟疾的疗效。方法选择2013年5月—2014年3月坦桑尼亚中坦友谊医院住院的恶性疟疾100例，按设定的治疗策略随机分为治疗组和对照组各50例。对照组：肌内注射80 mg蒿甲醚，1 d-1，连续治疗7 d，首次剂量160 mg；治疗组：在对照组的基础上，加服22.5 mg伯氨喹，1 d-1，连续服用8 d。依据恶性疟疾临床治愈标准，评价2组患者出院时疗效（痊愈、无效）并观察治疗期间的不良反应和治愈患者出院后28 d内的复发情况。结果治疗组和对照组痊愈、无效、复发率分别为98%、0、2%和82%、4%、14%，差异有统计学意义（P＜0.05）；总不良反应发生率分别为8%、16%，2组间差异有统计学意义（P＜0.05）。结论伯氨喹与蒿甲醚联合治疗可以提高恶性疟疾疗效，降低复发率，不良反应更少。
목적：평개백안규여호갑미연합치료악성학질적료효。방법선택2013년5월—2014년3월탄상니아중탄우의의원주원적악성학질100례，안설정적치료책략수궤분위치료조화대조조각50례。대조조：기내주사80 mg호갑미，1 d-1，련속치료7 d，수차제량160 mg；치료조：재대조조적기출상，가복22.5 mg백안규，1 d-1，련속복용8 d。의거악성학질림상치유표준，평개2조환자출원시료효（전유、무효）병관찰치료기간적불량반응화치유환자출원후28 d내적복발정황。결과치료조화대조조전유、무효、복발솔분별위98%、0、2%화82%、4%、14%，차이유통계학의의（P＜0.05）；총불량반응발생솔분별위8%、16%，2조간차이유통계학의의（P＜0.05）。결론백안규여호갑미연합치료가이제고악성학질료효，강저복발솔，불량반응경소。
Objective To evaluate the efficacy of primaquine and artemether combined treatment of falciparum malaria. Methods Selected patients who were hospitalized in Sino-Tanzania Friendship Hospital with falciparum malaria, collecting in time for the 2013 May to 2014 March, a total of 100 cases, among whom 86 were Tanzanian and 14 were Chinese. The patients were divided into 2 groups: 50 cases in the combined group, 50 cases in the control group. For combined therapy group, intramuscular injection of 80mg artemether was used once a day, for 7 consecutive days, the first dose of 160 mg, 22.5 mg primaquine was used once a day in the first days of taking artemether, lasting for 8 days; for the control group treatment: intramuscular injection of 80 mg artemether was used once a day for 7 consecutive days, with the first dose of 160 mg. The efficacy of hospital treatment in the two groups (recovery, invalid, reheat) and adverse reaction were evaluated. Results The combined group and the control group is invalid (98%, 0, 2%; 82%, 4%, 14%), the combined group and the control group, statistically significant differences is invalid, or (P<0.05); the incidence of adverse reaction in combined group and the control group was 8% and 16% respectively, the difference was statistically significant (P<0.05). Conclusion Primaquine and artemether combined therapy can improve the curative effect in the treatment of falciparum malaria, and reduce the probability of relapse, less adverse reaction.