中外医学研究
中外醫學研究
중외의학연구
CHINESE AND FOREIGN MEDICAL RESEARCH
2015年
14期
1-2
,共2页
谭鹤长%孟晓燕%何启锋%罗春明
譚鶴長%孟曉燕%何啟鋒%囉春明
담학장%맹효연%하계봉%라춘명
终末期肾病%血液透析%高尿酸血症%氧化应激
終末期腎病%血液透析%高尿痠血癥%氧化應激
종말기신병%혈액투석%고뇨산혈증%양화응격
End-stage renal disease%Hemodialysis%Hyperuricemia%Oxidative stress
目的：观察降尿酸治疗对血液透析(HD)患者氧化应激状态的改善作用。方法：选取51例血尿酸(SUA)>480μmol/L的HD患者作为研究对象，平均年龄(51.3±4.9)岁，平均透析年限(3.7±0.8)年，平均周透析时间(11.6±0.9)h。收集治疗前后血标本，检测SUA及氧化应激标志物8-羟基脱氧鸟苷(8-OHdG)和3-硝基酪氨酸修饰蛋白(3-NT)。结果：给予降尿酸治疗后，治疗后患者的SUA值比基线水平(512.4±109.8)μmol/L均显著降低(P<0.01)，氧化应激标志物8-OhdG为(0.97±0.43)ng/ml，较基线水平(1.93±0.94)ng/ml显著降低(P<0.01)，与SUA水平呈正相关，相关系数r为0.608，P<0.01，而3-NT则无显著性差异[(32.46±9.95)nM vs (29.23±9.63)nM，P=0.104]。结论：降尿酸治疗可改善血液透析患者的氧化应激状态，值得临床推广应用。
目的：觀察降尿痠治療對血液透析(HD)患者氧化應激狀態的改善作用。方法：選取51例血尿痠(SUA)>480μmol/L的HD患者作為研究對象，平均年齡(51.3±4.9)歲，平均透析年限(3.7±0.8)年，平均週透析時間(11.6±0.9)h。收集治療前後血標本，檢測SUA及氧化應激標誌物8-羥基脫氧鳥苷(8-OHdG)和3-硝基酪氨痠脩飾蛋白(3-NT)。結果：給予降尿痠治療後，治療後患者的SUA值比基線水平(512.4±109.8)μmol/L均顯著降低(P<0.01)，氧化應激標誌物8-OhdG為(0.97±0.43)ng/ml，較基線水平(1.93±0.94)ng/ml顯著降低(P<0.01)，與SUA水平呈正相關，相關繫數r為0.608，P<0.01，而3-NT則無顯著性差異[(32.46±9.95)nM vs (29.23±9.63)nM，P=0.104]。結論：降尿痠治療可改善血液透析患者的氧化應激狀態，值得臨床推廣應用。
목적：관찰강뇨산치료대혈액투석(HD)환자양화응격상태적개선작용。방법：선취51례혈뇨산(SUA)>480μmol/L적HD환자작위연구대상，평균년령(51.3±4.9)세，평균투석년한(3.7±0.8)년，평균주투석시간(11.6±0.9)h。수집치료전후혈표본，검측SUA급양화응격표지물8-간기탈양조감(8-OHdG)화3-초기락안산수식단백(3-NT)。결과：급여강뇨산치료후，치료후환자적SUA치비기선수평(512.4±109.8)μmol/L균현저강저(P<0.01)，양화응격표지물8-OhdG위(0.97±0.43)ng/ml，교기선수평(1.93±0.94)ng/ml현저강저(P<0.01)，여SUA수평정정상관，상관계수r위0.608，P<0.01，이3-NT칙무현저성차이[(32.46±9.95)nM vs (29.23±9.63)nM，P=0.104]。결론：강뇨산치료가개선혈액투석환자적양화응격상태，치득림상추엄응용。
Objective:To investigate the improvement effect of urate-lowering therapy on blood oxidative stress in hemodialysis(HD) patients. Method:51 HD patients who had serum uric acid (SUA) levels above 480μmol/L in our hospital were selected as research objects,the mean age was (51.3±4.9)years,the mean HD duration was (3.7±0.8)years,the mean dialysis time per week was (11.6±0.9)hours.Blood samples were collected for detecting SUA and oxidative stress markers(8-OhdG and 3-NT) before and after the treatment.Result:After urate-lowering therapy,the level of SUA in HD patients decreased significantly(P<0.01),comparing with the baseline level (512.4±109.8)μmol/L.The oxidative stress markers 8-hydroxy deoxyguanosine (8-OhdG ) also decreased significantly,comparing with the baseline level [(1.93±0.94)ng/ml vs (0.97±0.43)ng/ml,P<0.01],which were positively correlated with the level of SUA,the correlation coefficient was 0.608,P<0.01.However,the 3-nitrotyrosine modified protein (3-NT) was not significantly different from its baseline level [(32.46±9.95)nM vs (29.23±9.63)nM,P=0.104].Conclusion:Urate-lowering therapy can ameliorate the oxidative stress status in HD patients,is worthy of clinical application.
