CAJ | 학술논문

牛磺酸是人体内一种极为重要的氨基酸,也是中枢神经系统(CNS)中水平最为丰富的游离氨基酸.牛磺酸作为人体的一种条件必需氨基酸,具有广泛的生理药理作用.尤其在CNS的发育中,牛磺酸作为一种神经递质,能保持膜的结构完整性,调节钙的转运和稳态,还可作为营养因子、渗透剂、神经调节剂、神经保护剂发挥着重要作用.现就牛磺酸的理化性质、来源与分布、合成与代谢、吸收与转运,及其对CNS的保护作用做一综述.
우광산시인체내일충겁위중요적안기산,야시중추신경계통(CNS)중수평최위봉부적유리안기산.우광산작위인체적일충조건필수안기산,구유엄범적생리약리작용.우기재CNS적발육중,우광산작위일충신경체질,능보지막적결구완정성,조절개적전운화은태,환가작위영양인자、삼투제、신경조절제、신경보호제발휘착중요작용.현취우광산적이화성질、래원여분포、합성여대사、흡수여전운,급기대CNS적보호작용주일종술.
Taurine is one of the extremely important amino acids in the body,and is also the most abundant free amino acids in the central nervous system(CNS).Taurine as a conditional essential amino acids exerts a wide range of physiological and pharmacological effects.Taurine,especially as a neurotransmitter in the developing CNS,can maintain the structural integrity of the membrane,regulate calcium transport and calcium homeostasis,also as nutritional factors,osmolyte,neuromodulator,neuroprotective agents,plays an important role.In this paper,physiological and biochemical properties of taurine,source and distribution in vivo,synthesis and metabolism,absorption and transport,and its protective effect on the CNS are reviewed.