CAJ | 학술논문

目的分析我国居民食物消费水平及食物中邻苯二甲酸二(2-乙基己基)酯(DEHP)含量,评估我国居民膳食DEHP的暴露水平及其风险.方法于2011-2013年,采用分层整群随机抽样方法,选取中国14个省份的70个城市的140个超市或集贸市场为采样点,共采集22类食物样品6 650份.采用气相色谱-质谱联用方法,检测食物中DEHP的含量.利用食物中DEHP平均含量和2002年“中国居民营养与健康状况调查”数据中68 959名调查对象的食物消费量,采用简单分布模型计算不同年龄组人群膳食DEHP摄入水平以及不同种类食物对膳食DEHP摄人的贡献率,并与DEHP的每日可耐受摄入量(TDI,50μg·kg-1 ·d-1)比较,进行风险特征描述.结果 6 650份样品中DEHP含量范围为未检出～43.80 mg/kg.膳食DEHP平均摄入量为2.07(95％ CI:0.06～4.09) μg· kg-1·d-1,占TDI(50 μg· kg-1·d-1)的4.14％.2～6、7～12、13 ～ 17、18 ～59、≥60岁组膳食DEHP摄人量分别为3.92(95％ CI:0.83 ～7.01)、3.02(95％ CI:0.69～5.36)、2.17(95％ CI:0.54～3.81)、1.83(95％ CI:0.46 ～3.21)和1.66(95％ CI:0.38～ 2.94) μg·kg-1·d-1.全人群高食物消费量人群(P97.5)为4.73 μg·kg-1 ·d-1,占TDI(50 μg·kg-1 ·d-1)的9.46％.大米、瓜茄果类蔬菜、面粉对DEHP膳食摄入的贡献率分别为28.4％(0.59/2.07)、14.7％(0.30/2.07)、13.2％(0.27/2.07).结论中国居民膳食DEHP摄入水平低于健康指导值;DEHP暴露风险较低;大米、瓜茄果类蔬菜、面粉是人群DEHP膳食摄人的主要来源.
목적 분석아국거민식물소비수평급식물중린분이갑산이(2-을기기기)지(DEHP)함량,평고아국거민선식DEHP적폭로수평급기풍험.방법 우2011-2013년,채용분층정군수궤추양방법,선취중국14개성빈적70개성시적140개초시혹집무시장위채양점,공채집22류식물양품6 650빈.채용기상색보-질보련용방법,검측식물중DEHP적함량.이용식물중DEHP평균함량화2002년“중국거민영양여건강상황조사”수거중68 959명조사대상적식물소비량,채용간단분포모형계산불동년령조인군선식DEHP섭입수평이급불동충류식물대선식DEHP섭인적공헌솔,병여DEHP적매일가내수섭입량(TDI,50μg·kg-1 ·d-1)비교,진행풍험특정묘술.결과 6 650빈양품중DEHP함량범위위미검출～43.80 mg/kg.선식DEHP평균섭입량위2.07(95％ CI:0.06～4.09) μg· kg-1·d-1,점TDI(50 μg· kg-1·d-1)적4.14％.2～6、7～12、13 ～ 17、18 ～59、≥60세조선식DEHP섭인량분별위3.92(95％ CI:0.83 ～7.01)、3.02(95％ CI:0.69～5.36)、2.17(95％ CI:0.54～3.81)、1.83(95％ CI:0.46 ～3.21)화1.66(95％ CI:0.38～ 2.94) μg·kg-1·d-1.전인군고식물소비량인군(P97.5)위4.73 μg·kg-1 ·d-1,점TDI(50 μg·kg-1 ·d-1)적9.46％.대미、과가과류소채、면분대DEHP선식섭입적공헌솔분별위28.4％(0.59/2.07)、14.7％(0.30/2.07)、13.2％(0.27/2.07).결론 중국거민선식DEHP섭입수평저우건강지도치;DEHP폭로풍험교저;대미、과가과류소채、면분시인군DEHP선식섭인적주요래원.
Objective To assess dietary exposure of diethylhexyl phthalate(DEHP) among Chinese population,including general population,children aged 2-6 years,adolescent aged 7-12,young people aged 13-17,adults aged 18-59 years old as well as older people aged 60 and above and its health risk.Methods A total of 6 650 food samples were collected during 2011 to 2013 from 140 local markets of 14 provinces in China,which covered major foods in China.Samples were detected by GC-MS and categorized into 22 food groups.Food consumption data were taken from China National Nutrition and Health Survey performed in 2002 including 68 959 subjects.Mean concentrations of DEHP in food were combined with individual food consumption data to estimate dietary exposure,and food contributors to dietary DEHP intake were also calculated.Then,the exposure was compared with the tolerable daily intake (TDI,50 μg · kg-1 · d-1) of DEHP.Results DEHP level in foods (n =6 650) was in the range of not detected to 43.80 mg/kg.Mean dietary intakes of DEHP in general population was 2.07 (95％ CI:0.06-4.09) μg · kg-1 · d-1,accounting for 4.14 percent of TDI(50 μg · kg-1 · d-1).Mean dietary intake for population aged 2-6,7-12,13-17,18-59 as well as elderly aged 60 and above were 3.92 (95％ CI:0.83-7.01),3.02(95％ CI:0.69-5.36),2.17(95％CI:0.54-3.81),1.83(95％CI:0.46-3.21) and 1.66(95％ CI:0.38-2.94) μg · kg-1 · d-1 respectively.The 97.5 percentile intakes in the general populations was 4.73 μg · kg 1 · d-1,accounting for 9.46％ of TDI.Main food sources of DEHP were rice (28.4％ (0.59/2.07)),melon solanaceous vegetables (14.7％ (0.30/2.07)) and flour (13.2％ (0.27/ 2.07)) for the general population.Conclusion The results suggested that dietary exposure to DEHP among Chinese population was lower than tolerable daily intake of DEHP and there were no health concerns based on generally accepted exposure linits.Rice,melon solanaceous vegetables and flour were main food contributors of DEHP dietary intake for Chinese populations.