CAJ | 학술논문

目的探讨经典原位肝移植术中改良逆灌注技术(逆行灌注改良法)对移植肝的影响.方法收集2011年3月至2014年9月我院108例肝病患者肝移植手术资料.其中经典原位肝移植术中逆行灌注法手术治疗63例,经典原位肝移植术中逆行灌注改良法手术治疗45例.采用倾向评分配比法(PSM)均衡组间协变量,获得匹配患者并对其进行术后肝功能恢复疗效分析.结果经PSM匹配后得到27对患者.匹配后逆行灌注改良法组患者移植术后肝功能恢复较快.与逆行灌注法组比较,术后第1天、第3天、第5天、第7天碱性磷酸酶(AKP)、总胆红素(TBil)、丙氨酸转氨酶(ALT)、谷氨酰转肽酶(GGT)、天冬氨酸转氨酶(AST)差异有统计学意义(P＜0.05).结论采用经典原位肝移植术中逆行灌注改良法可改善移植肝早期肝功能,加快肝功能恢复,从而更有效提高肝移植的整体疗效.
목적 탐토경전원위간이식술중개량역관주기술(역행관주개량법)대이식간적영향.방법 수집2011년3월지2014년9월아원108례간병환자간이식수술자료.기중경전원위간이식술중역행관주법수술치료63례,경전원위간이식술중역행관주개량법수술치료45례.채용경향평분배비법(PSM)균형조간협변량,획득필배환자병대기진행술후간공능회복료효분석.결과 경PSM필배후득도27대환자.필배후역행관주개량법조환자이식술후간공능회복교쾌.여역행관주법조비교,술후제1천、제3천、제5천、제7천감성린산매(AKP)、총담홍소(TBil)、병안산전안매(ALT)、곡안선전태매(GGT)、천동안산전안매(AST)차이유통계학의의(P＜0.05).결론 채용경전원위간이식술중역행관주개량법가개선이식간조기간공능,가쾌간공능회복,종이경유효제고간이식적정체료효.
Objective To study the impact of an improved retrograde perfusion technique (the improved retrograde perfusion method) on liver transplantation.Methods The data on 108 patients who underwent liver transplantation from March 2011 to September 2014 in our hospital were analyzed.Orthotopic liver transplantation with retrograde perfusion was carried out in 63 patients,while orthotopic liver transplantation with the improved retrograde perfusion method was carried out in 45 patients.Propensity score matching (PSM) was used to balance covariates between the two groups.Results After PSM matching there were 27 pairs of patients,and a comparison between the improved retrograde perfusion method group and the retrograde perfusion method was carried out.There were significant difference in alkaline phosphatase (AKP),total bilirubin (TBil),alanine aminotransferase (ALT),gamma glutamyl transpeptidase (GGT),aspertate aminotransferase (AST) (P ＜0.05) on postoperative day 1,day 3,day 5,day 7 between the two groups.Conclusion The improved retrograde perfusion method improved liver function,accelerated recovery of liver function,and was more efficacious than the retrograde perfusion method in orthotopic liver transplantation.