CAJ | 학술논문

原发性肝癌(primary hepatic carcinoma, PHC)的早期发现和诊断是肝癌诊疗领域中的重要课题之一。近些年来，对分子影像学(Molecular Imaging)研究的不断深入，为肝细胞癌的早期检测和早期诊断提供了一种全新的思维方法。相对于传统的磁共振对比剂钆剂，超顺磁性氧化铁(superparamagnetic iron oxide, SPIO)具有很多优点，能够产生磁共振负性强化。在生物医学领域，超顺磁性氧化铁的应用很多，可以作为载体应用在多个方面，例如靶向探针的载体、携带药物的载体等，作为科研热点在分子影像学方面被充分关注。本文通过总结既往的研究，对SPIO纳米颗粒在肝癌磁共振早期诊断的基础研究进展进行综述。
원발성간암(primary hepatic carcinoma, PHC)적조기발현화진단시간암진료영역중적중요과제지일。근사년래，대분자영상학(Molecular Imaging)연구적불단심입，위간세포암적조기검측화조기진단제공료일충전신적사유방법。상대우전통적자공진대비제구제，초순자성양화철(superparamagnetic iron oxide, SPIO)구유흔다우점，능구산생자공진부성강화。재생물의학영역，초순자성양화철적응용흔다，가이작위재체응용재다개방면，례여파향탐침적재체、휴대약물적재체등，작위과연열점재분자영상학방면피충분관주。본문통과총결기왕적연구，대SPIO납미과립재간암자공진조기진단적기출연구진전진행종술。
Early detection and diagnosis of liver cancer is an important issue that must be addressed. The development of molecular imaging provides a new way for early detection and diagnosis of hepatocellular carcinoma. Superparamagnetic iron oxide(SPIO) has a broad application prospect in biomedical ifeld, and becomes a hot spot in the field of molecular imaging research currently. Compared to traditional magnetic resonance imaging(MRI) contrast medium(gadolinium), SPIO has many advantages, and can lead to negative enhancement for MRI. SPIO has wide applications in the biomedical ifeld and can be used as not only as a drug-release carrier but also as a targeted probe carrier. SPIO has recently gained much attention in the field of molecular imaging research. SPIO is a speciifc MRI contrast agent for liver imaging and plays an important role in the diagnosis of hepatocellular carcinoma.