中国医药
中國醫藥
중국의약
CHINA MEDICINE
2015年
5期
700-702
,共3页
急性化脓性扁桃体炎%小儿%克林霉素%促炎因子
急性化膿性扁桃體炎%小兒%剋林黴素%促炎因子
급성화농성편도체염%소인%극림매소%촉염인자
Acute suppurative tonsillitis%Children%Clindamycin%Proinflammatory cytokine
目的 探讨克林霉素注射液联合喜炎平注射液治疗小儿急性化脓性扁桃体炎的有效性及安全性.方法 选取2013年10月至2014年10月广州医科大学附属第三医院收治的急性化脓性扁桃体炎患儿100例,根据随机数字表法分为观察组和对照组,每组50例.对照组仅给予克林霉素注射液治疗,观察组给予喜炎平注射液联合克林霉素注射液治疗.比较2组患儿临床症状消失时间、血清促炎因子表达水平及临床疗效.结果 观察组患儿体温恢复正常时间、咽喉疼痛消失时间、扁桃体充血消退时间及脓性分泌物消失时间均明显短于对照组[(37±6)h比(65±4)h,(47 ±4)h比(79 ±6)h,(41±7)h比(76 ±6)h,(43 ±5)h比(60±6)h],差异均有统计学意义(均P＜0.05).治疗后,观察组患儿血清白细胞介素6(IL-6)、IL-8、肿瘤坏死因子α等促炎因子表达水平均明显低于对照组[(18±3) U/L比(26±3)U/L,(7.2±1.8)U/L比(13.2±2.4)U/L,(24±4) U/L比(32 ±3) U/L],差异均有统计学意义(均P＜0.05).观察组治疗总有效率明显高于对照组[98.0％ (49/50)比78.0％(39/50)],差异有统计学意义(P＜0.05).结论 喜炎平注射液联合克林霉素注射液治疗小儿急性化脓性扁桃体炎的疗效优于单纯克林霉素注射液治疗,抑制机体促炎因子表达是其可能作用机制.
目的 探討剋林黴素註射液聯閤喜炎平註射液治療小兒急性化膿性扁桃體炎的有效性及安全性.方法 選取2013年10月至2014年10月廣州醫科大學附屬第三醫院收治的急性化膿性扁桃體炎患兒100例,根據隨機數字錶法分為觀察組和對照組,每組50例.對照組僅給予剋林黴素註射液治療,觀察組給予喜炎平註射液聯閤剋林黴素註射液治療.比較2組患兒臨床癥狀消失時間、血清促炎因子錶達水平及臨床療效.結果 觀察組患兒體溫恢複正常時間、嚥喉疼痛消失時間、扁桃體充血消退時間及膿性分泌物消失時間均明顯短于對照組[(37±6)h比(65±4)h,(47 ±4)h比(79 ±6)h,(41±7)h比(76 ±6)h,(43 ±5)h比(60±6)h],差異均有統計學意義(均P＜0.05).治療後,觀察組患兒血清白細胞介素6(IL-6)、IL-8、腫瘤壞死因子α等促炎因子錶達水平均明顯低于對照組[(18±3) U/L比(26±3)U/L,(7.2±1.8)U/L比(13.2±2.4)U/L,(24±4) U/L比(32 ±3) U/L],差異均有統計學意義(均P＜0.05).觀察組治療總有效率明顯高于對照組[98.0％ (49/50)比78.0％(39/50)],差異有統計學意義(P＜0.05).結論 喜炎平註射液聯閤剋林黴素註射液治療小兒急性化膿性扁桃體炎的療效優于單純剋林黴素註射液治療,抑製機體促炎因子錶達是其可能作用機製.
목적 탐토극림매소주사액연합희염평주사액치료소인급성화농성편도체염적유효성급안전성.방법 선취2013년10월지2014년10월엄주의과대학부속제삼의원수치적급성화농성편도체염환인100례,근거수궤수자표법분위관찰조화대조조,매조50례.대조조부급여극림매소주사액치료,관찰조급여희염평주사액연합극림매소주사액치료.비교2조환인림상증상소실시간、혈청촉염인자표체수평급림상료효.결과 관찰조환인체온회복정상시간、인후동통소실시간、편도체충혈소퇴시간급농성분비물소실시간균명현단우대조조[(37±6)h비(65±4)h,(47 ±4)h비(79 ±6)h,(41±7)h비(76 ±6)h,(43 ±5)h비(60±6)h],차이균유통계학의의(균P＜0.05).치료후,관찰조환인혈청백세포개소6(IL-6)、IL-8、종류배사인자α등촉염인자표체수평균명현저우대조조[(18±3) U/L비(26±3)U/L,(7.2±1.8)U/L비(13.2±2.4)U/L,(24±4) U/L비(32 ±3) U/L],차이균유통계학의의(균P＜0.05).관찰조치료총유효솔명현고우대조조[98.0％ (49/50)비78.0％(39/50)],차이유통계학의의(P＜0.05).결론 희염평주사액연합극림매소주사액치료소인급성화농성편도체염적료효우우단순극림매소주사액치료,억제궤체촉염인자표체시기가능작용궤제.
Objective To evaluate the effect and safety of clindamycin combined with Xiyanping injection in treating acute suppurative tonsillitis in children.Methods One hundred children with acute suppurative tonsillitis from October 2013 to October 2014 were selected and randomly divided into control group (50 cases) receiving clindamycin injection and observation group (50 cases) receiving clindamycin injection combined with Xiyanping injection.The time of clinical symptoms disappearance,level of serum proinflammatory cytokine and clinical efficacy were evaluated and compared between the two groups.Results The disappearance time of hyperthermia,pharyngalgia,antiadoncus and purulent secretion in observation group were all significantly shorter than those in control group [(37 ±6) h vs (65 ±4) h,(47 ±4) h vs (79 ±6) h,(41 ±7) h vs (76 ±6) h,(43 ±5) h vs (60 ±6) h] (P ＜0.05).The levels of interleukin-6 (IL-6),IL-8 and tumor necrosis factor-α (TNF-α) in observation group were significantly lower than those in control group [(18 ± 3) U/L vs (26 ± 3) U/L,(7.2 ± 1.8) U/L vs (13.2 ±2.4) U/L,(24 ±4) U/Lvs (32 ±3) U/L] (P＜0.05).The clinical efficacy of observation group was significantly higher than that of control group [98.0％ (49/50) vs 78.0％ (39/50)] (P ＜ 0.05).Conclusion The effect of clindamycin combined with Xiyanping injection is superior to single use of clindamycin in treatment of acute suppurative tonsillitis in children,which may be related to the inhibition of proinflammatory cytokine expression.
