CAJ | 학술논문

目的：观察微动力负压护创敷料对兔Ⅱ度烧伤创面愈合的影响。方法健康成年新西兰大耳兔8只，采用电子恒温恒压电烫仪90℃烫其背部12 s 造成Ⅱ度烧伤创面，每只兔背部共烫伤4个Ⅱ度烫伤创面。采取左右自身对照，左侧为微动力负压护创敷料的治疗组，右侧为采用凡士林纱布覆盖、无菌纱布包扎的对照组。烫伤后即刻和治疗后第1、3、5、7天共5个时相点分别采集创面皮肤组织标本，干湿重法测定创面组织含水量，采用激光多普勒血流仪测定创面微循环血流量，并观察创面愈合情况。结果治疗后第1、3、5、7天，治疗组创面组织含水量显著低于对照组，两组比较差异均有统计学意义（t ＝5．067、5．133、4．464、3．875，P ＝0．001、0．001、0．003、0．006），治疗后第3、5、7天，创面微循坏血流量治疗组明显高于对照组，两组比较差异均有统计学意义（t ＝－3．155、－4．835、－7．168，P ＝0．016、0．020、0．000）。治疗组第14天和第20天的创面愈合率均显著高于对照组，两组比较差异均有统计学意义（t ＝－39．052、－11．223，P ＝0．000、0．000），治疗组的创面愈合时间为（20．9±2．2）d，对照组的创面愈合时间为（23．0±2．4）d，两组比较差异有统计学意义（t ＝9．379，P ＝0．000）。结论微动力负压护创敷料可减轻创面水肿，增加兔Ⅱ度烧伤创面微循环血流量，缩短创面愈合时间。
목적：관찰미동력부압호창부료대토Ⅱ도소상창면유합적영향。방법건강성년신서란대이토8지，채용전자항온항압전탕의90℃탕기배부12 s 조성Ⅱ도소상창면，매지토배부공탕상4개Ⅱ도탕상창면。채취좌우자신대조，좌측위미동력부압호창부료적치료조，우측위채용범사림사포복개、무균사포포찰적대조조。탕상후즉각화치료후제1、3、5、7천공5개시상점분별채집창면피부조직표본，간습중법측정창면조직함수량，채용격광다보륵혈류의측정창면미순배혈류량，병관찰창면유합정황。결과치료후제1、3、5、7천，치료조창면조직함수량현저저우대조조，량조비교차이균유통계학의의（t ＝5．067、5．133、4．464、3．875，P ＝0．001、0．001、0．003、0．006），치료후제3、5、7천，창면미순배혈류량치료조명현고우대조조，량조비교차이균유통계학의의（t ＝－3．155、－4．835、－7．168，P ＝0．016、0．020、0．000）。치료조제14천화제20천적창면유합솔균현저고우대조조，량조비교차이균유통계학의의（t ＝－39．052、－11．223，P ＝0．000、0．000），치료조적창면유합시간위（20．9±2．2）d，대조조적창면유합시간위（23．0±2．4）d，량조비교차이유통계학의의（t ＝9．379，P ＝0．000）。결론미동력부압호창부료가감경창면수종，증가토Ⅱ도소상창면미순배혈류량，축단창면유합시간。
Objective To investigate the effect of micropower vacuum dressingson the healing of rabbit second degree burn wound.Methods Eight adult healthy rabbits were performed a second degree burn,which was obtained on the dorsal skin using electrons homeothermia burn instrument 90℃ for 1 2 s. Four wounds were performed symmetrically on the back of each rabbit in a self-control situation.One site was set as the treatment group treated with the micropower vacuum dressings and the other site was the control group,treated with vaseline gauze.Immediately after burn and 1 ,3,5,7 d postburn,the wounds were harvested and water content was examined by dry to wet weight method.Wound microcirculation blood flow was determined using the laser doppler flowmetry and wound healing process was also detected.Results On the 1 ,3,5,7 d postburn,wound tissue water content in the treatment group was significantly lower than that of the control group,the difference was statistically significant (t =5.067,5.1 33,4.464,3.875, P =0.001 ,0.001 ,0.003,0.006).On the 3 d,5 d and 7 d postburn,wound microcirculation blood flow in the treatment group was significantly higher than that of the control group,the difference was statistically significant (t =-3.1 55,-4.835,-7.1 68,P =0.01 6,0.020,0.000).On the 1 4 d and 20 d postburn, the wound healing rate in the treatment group was significantly higher than that of the control group the difference was statistically significant (t =-39.052, -1 1 .223,P =0.000,0.000).In the treatment group,the wound healing time was (20.9 ±2.2)d,which was shorter than that of the control group,the difference was statistically significant (t =9.379,P =0.000).Conclusion Micropower vacuum dressings can reduce tissue edema,increase microcirculatory blood flow of rabbit second degree burn wound,and shorten the time of wound healing.