CAJ | 학술논문

目的：研究与分析盐酸曲美他嗪治疗冠心病稳定型心绞痛的临床疗效。方法：将102例冠心病稳定型心绞痛患者按照随机数字表法分为对照组和治疗组。对照组采用常规药物治疗；治疗组在对照组基础上加用盐酸曲美他嗪治疗。比较两组临床疗效、血脂变化及不良反应。结果：治疗后，两组血脂水平均有明显改善，且治疗组改善程度优于对照组（P<0.05）。治疗组治疗心绞痛有效率和不良反应发生率分别为92.16%（47/51）、3.92%（2/51），与对照组的80.39%（41/51）、13.73%（7/51）比较差异均有统计学意义（P<0.05）。治疗组心电图疗效优于对照组（P<0.05）。结论：盐酸曲美他嗪治疗冠心病稳定型心绞痛可有效改善患者血脂水平，缓解心绞痛，提高临床疗效，且不良反应少。
목적：연구여분석염산곡미타진치료관심병은정형심교통적림상료효。방법：장102례관심병은정형심교통환자안조수궤수자표법분위대조조화치료조。대조조채용상규약물치료；치료조재대조조기출상가용염산곡미타진치료。비교량조림상료효、혈지변화급불량반응。결과：치료후，량조혈지수평균유명현개선，차치료조개선정도우우대조조（P<0.05）。치료조치료심교통유효솔화불량반응발생솔분별위92.16%（47/51）、3.92%（2/51），여대조조적80.39%（41/51）、13.73%（7/51）비교차이균유통계학의의（P<0.05）。치료조심전도료효우우대조조（P<0.05）。결론：염산곡미타진치료관심병은정형심교통가유효개선환자혈지수평，완해심교통，제고림상료효，차불량반응소。
Objective:To study and analyze clinical curative effect of trimetazidine hydrochloride in treatment of stable coronary heart disease angina pectoris.Method:102 patients with stable coronary artery disease angina were grouped into control group and treatment group.The control group used the conventional drugs such as aspirin treatment. The treatment group used trimetazidine hydrochloride on the basis of the control group.Clinical curative effect and blood lipid changes and adverse reactions of two groups were compared.Result:After treatment, lipid levels of two groups were significantly changed, and the treatment group was better than that of control group(P<0.05).Angina pectoris effectiveness and adverse reaction rate of treatment group were 92.16%(47/51),3.92%(2/51) and 80.39% (41/51), 13.73% (7/51) of control group (P<0.05).Electrocardiogram curative effect of the treatment group was better than that of control group (P<0.05).Conclusion:Trimetazidine hydrochloride treatment of coronary heart disease patients with stable angina, can effectively improve the blood lipid level, relieve angina and improve clinical curative effect, and less adverse reaction.