CAJ | 학술논문

三氯乙烯(trichloroethylene)是用途广泛的有机溶剂和重要的工业原料,易在制造、使用和弃置过程中释放入环境,因此广泛存在职业和环境暴露人群.国际癌症研究中心(IARC)于2012年根据积累的研究资料将三氯乙烯从人类可能致癌物提高评级到人类致癌物.本文从人群流行病学资料、动物实验证据以及致癌机制等几个方面概述了三氯乙烯及其代谢物的致癌作用.
삼록을희(trichloroethylene)시용도엄범적유궤용제화중요적공업원료,역재제조、사용화기치과정중석방입배경,인차엄범존재직업화배경폭로인군.국제암증연구중심(IARC)우2012년근거적루적연구자료장삼록을희종인류가능치암물제고평급도인류치암물.본문종인군류행병학자료、동물실험증거이급치암궤제등궤개방면개술료삼록을희급기대사물적치암작용.
Trichlorethylene (TCE) is a widely used organic solvent and an important industrial material.It's easily released into the environment through manufacture,use and disposal process,so there is a wide range of occupationally and environmentally exposed population.Based on accumulated research data,International Agency for Research on Cancer (IARC) increased the carcinogenic rating of TCE from probable human carcinogen to certain human carcinogen in 2012.This paper is a review of the carcinogenic effects of TCE and its metabolites from the aspects of epidemiological data,experimental evidence on animals as well as the mechanisms of carcinogenesis.