中国医药
中國醫藥
중국의약
CHINA MEDICINE
2015年
5期
649-651
,共3页
糖尿病,2型%颈动脉斑块%同型半胱氨酸%高敏C反应蛋白%瑞舒伐他汀
糖尿病,2型%頸動脈斑塊%同型半胱氨痠%高敏C反應蛋白%瑞舒伐他汀
당뇨병,2형%경동맥반괴%동형반광안산%고민C반응단백%서서벌타정
Diabetes mellitus,type 2%Carotid artery plaque%Homocysteine%High-sensitivity C reactive protein%Rosuvastatin
目的 探讨瑞舒伐他汀对老年2型糖尿病合并颈动脉斑块患者同型半胱氨酸(Hcy)、高敏C反应蛋白(hs-CRP)及血脂的影响.方法 将96例老年2型糖尿病合并颈动脉斑块患者使用随机数字表法分为对照组(46例)和观察组(50例).对照组进行常规治疗,观察组在常规治疗基础上加用瑞舒伐他汀5 mg/d,口服.比较2组患者治疗前和治疗后6周hs-CRP、Hcy、空腹血糖、三酰甘油、总胆固醇、低密度脂蛋白胆固醇(LDL-C)、高密度脂蛋白胆固醇水平.结果 治疗后,观察组总胆固醇、LDL-C、hs-CRP、Hcy均明显低于对照组,差异均有统计学意义[总胆固醇:(4.1±l.2)mmol/L比(4.6±0.9) mmol/L,LDL-C:(2.2±0.6) mmol/L比(2.6±0.6) mmol/L,hs-CRP:(12±4)mg/L比(14±4) mg/L,Hcy:(13±4) μmol/L比(15 ±3)μmol/L](均P＜0.05).2组患者治疗前后肾功能、尿常规无明显变化.观察组l例患者肝功能受损,未停药,加用益肝灵口服2周后肝功能恢复.结论 瑞舒伐他汀可以降低老年2型糖尿病合并颈动脉斑块患者血脂、Hcv和hs-CRP水平.
目的 探討瑞舒伐他汀對老年2型糖尿病閤併頸動脈斑塊患者同型半胱氨痠(Hcy)、高敏C反應蛋白(hs-CRP)及血脂的影響.方法 將96例老年2型糖尿病閤併頸動脈斑塊患者使用隨機數字錶法分為對照組(46例)和觀察組(50例).對照組進行常規治療,觀察組在常規治療基礎上加用瑞舒伐他汀5 mg/d,口服.比較2組患者治療前和治療後6週hs-CRP、Hcy、空腹血糖、三酰甘油、總膽固醇、低密度脂蛋白膽固醇(LDL-C)、高密度脂蛋白膽固醇水平.結果 治療後,觀察組總膽固醇、LDL-C、hs-CRP、Hcy均明顯低于對照組,差異均有統計學意義[總膽固醇:(4.1±l.2)mmol/L比(4.6±0.9) mmol/L,LDL-C:(2.2±0.6) mmol/L比(2.6±0.6) mmol/L,hs-CRP:(12±4)mg/L比(14±4) mg/L,Hcy:(13±4) μmol/L比(15 ±3)μmol/L](均P＜0.05).2組患者治療前後腎功能、尿常規無明顯變化.觀察組l例患者肝功能受損,未停藥,加用益肝靈口服2週後肝功能恢複.結論 瑞舒伐他汀可以降低老年2型糖尿病閤併頸動脈斑塊患者血脂、Hcv和hs-CRP水平.
목적 탐토서서벌타정대노년2형당뇨병합병경동맥반괴환자동형반광안산(Hcy)、고민C반응단백(hs-CRP)급혈지적영향.방법 장96례노년2형당뇨병합병경동맥반괴환자사용수궤수자표법분위대조조(46례)화관찰조(50례).대조조진행상규치료,관찰조재상규치료기출상가용서서벌타정5 mg/d,구복.비교2조환자치료전화치료후6주hs-CRP、Hcy、공복혈당、삼선감유、총담고순、저밀도지단백담고순(LDL-C)、고밀도지단백담고순수평.결과 치료후,관찰조총담고순、LDL-C、hs-CRP、Hcy균명현저우대조조,차이균유통계학의의[총담고순:(4.1±l.2)mmol/L비(4.6±0.9) mmol/L,LDL-C:(2.2±0.6) mmol/L비(2.6±0.6) mmol/L,hs-CRP:(12±4)mg/L비(14±4) mg/L,Hcy:(13±4) μmol/L비(15 ±3)μmol/L](균P＜0.05).2조환자치료전후신공능、뇨상규무명현변화.관찰조l례환자간공능수손,미정약,가용익간령구복2주후간공능회복.결론 서서벌타정가이강저노년2형당뇨병합병경동맥반괴환자혈지、Hcv화hs-CRP수평.
Objective To investigate the effects of rosuvastatin on blood homocysteine (Hcy),high-sensitivity C reactive protein (hs-CRP) and blood lipid in the elderly patients with type 2 diabetes mellitus complicated with carotid artery plaque.Methods Ninety-six senile patients with type 2 diabetes complicated with carotid artery plaque were randomly divided into control group (46 cases) receiving conventional treatment and observation group (50 cases) taking oral rosuvastatin (5 mg/d) in addition to conventional treatment.Before and 6 weeks after treatment,the levels of Hcy,hs-CRP,blood glucose,triglycerides (TG),total cholesterol (TC),low density lipoprotein cholesterol (LDL-C) and high-density lipoprotein cholesterol (HDL-C) were measured and compared between the two groups.Results The levels of blood hs-CRP,TG,TC,LDL-C,Hcy in observation group were significantly lower than those in control group [TC:(4.1 ± 1.2) mmol/L vs (4.6 ± 0.9) mmol/L,LDL-C:(2.2±0.6) mmol/L vs (2.6±0.6) mmol/L,hs-CRP:(12±4) mg/L vs (14±4) mg/L,Hcy:(13±4) μmol/L vs (15 ± 3) μmol/L] (P ＜ 0.05).No significant changes of renal function and routine urine test were found after treatment in both the two groups.One case in observation group had impaired fiver function and recovered after taking oral silymarin for two weeks.Conclusion Rosuvastatin can decrease the levels of blood TG,TC,LDL-C,Hcy and hs-CRP in the elderly patients with type 2 diabetes mellitus complicatred with carotid plaque.
