中国医药
中國醫藥
중국의약
CHINA MEDICINE
2015年
5期
664-666
,共3页
钟丽萍%潘月芬%沈俊俊%齐全%廖海红
鐘麗萍%潘月芬%瀋俊俊%齊全%廖海紅
종려평%반월분%침준준%제전%료해홍
艾迪注射液%博来霉素%胸腔积液,恶性%治疗结果
艾迪註射液%博來黴素%胸腔積液,噁性%治療結果
애적주사액%박래매소%흉강적액,악성%치료결과
Addie injection%Bleomycin%Pleural effusion,malignant%Treatment outcome
目的 观察艾迪注射液联合博来霉素治疗恶性胸腔积液的临床疗效.方法 将90例恶性胸腔积液患者完全随机分为观察组和对照组,各45例,2组患者均采用胸腔放置引流管放净胸腔积液.对照组每次胸腔内注射博来霉素45 ～ 60 mg+0.9％氯化钠注射液40 ml+地塞米松5 mg+利多卡因注射液5 ml;观察组患者在对照组基础上加注艾迪注射液50 ml,1周后重复胸腔内注入,持续3周.治疗4周后,观察和比较2组的临床疗效、不良反应发生率和一般生活状况评分(KPS评分).结果 治疗4周后,观察组有效率[86.7％ (39/45)]明显高于对照组[55.6％(25/45)],KPS评分[(79±6)分]明显高于对照组[(73±6)分],患者生活质量改善率[75.6％(34/45)]明显高于对照组[42.2％ (19/45)],差异均有统计学意义(均P＜0.05).观察组不良反应发生率[22.2％ (10/45)]明显低于对照组[68.9％ (31/45)],差异有统计学意义(P＜0.05).结论 艾迪注射液联合博来霉素治疗恶性胸腔积液较单用博来霉素的近期疗效及生活质量均明显提高,不良反应发生率明显降低.
目的 觀察艾迪註射液聯閤博來黴素治療噁性胸腔積液的臨床療效.方法 將90例噁性胸腔積液患者完全隨機分為觀察組和對照組,各45例,2組患者均採用胸腔放置引流管放淨胸腔積液.對照組每次胸腔內註射博來黴素45 ～ 60 mg+0.9％氯化鈉註射液40 ml+地塞米鬆5 mg+利多卡因註射液5 ml;觀察組患者在對照組基礎上加註艾迪註射液50 ml,1週後重複胸腔內註入,持續3週.治療4週後,觀察和比較2組的臨床療效、不良反應髮生率和一般生活狀況評分(KPS評分).結果 治療4週後,觀察組有效率[86.7％ (39/45)]明顯高于對照組[55.6％(25/45)],KPS評分[(79±6)分]明顯高于對照組[(73±6)分],患者生活質量改善率[75.6％(34/45)]明顯高于對照組[42.2％ (19/45)],差異均有統計學意義(均P＜0.05).觀察組不良反應髮生率[22.2％ (10/45)]明顯低于對照組[68.9％ (31/45)],差異有統計學意義(P＜0.05).結論 艾迪註射液聯閤博來黴素治療噁性胸腔積液較單用博來黴素的近期療效及生活質量均明顯提高,不良反應髮生率明顯降低.
목적 관찰애적주사액연합박래매소치료악성흉강적액적림상료효.방법 장90례악성흉강적액환자완전수궤분위관찰조화대조조,각45례,2조환자균채용흉강방치인류관방정흉강적액.대조조매차흉강내주사박래매소45 ～ 60 mg+0.9％록화납주사액40 ml+지새미송5 mg+리다잡인주사액5 ml;관찰조환자재대조조기출상가주애적주사액50 ml,1주후중복흉강내주입,지속3주.치료4주후,관찰화비교2조적림상료효、불량반응발생솔화일반생활상황평분(KPS평분).결과 치료4주후,관찰조유효솔[86.7％ (39/45)]명현고우대조조[55.6％(25/45)],KPS평분[(79±6)분]명현고우대조조[(73±6)분],환자생활질량개선솔[75.6％(34/45)]명현고우대조조[42.2％ (19/45)],차이균유통계학의의(균P＜0.05).관찰조불량반응발생솔[22.2％ (10/45)]명현저우대조조[68.9％ (31/45)],차이유통계학의의(P＜0.05).결론 애적주사액연합박래매소치료악성흉강적액교단용박래매소적근기료효급생활질량균명현제고,불량반응발생솔명현강저.
Objective To investigate the effect of Addie injection combined with bleomycin in treatment of malignant pleural effusion.Methods Ninety patients of malignant pleural effusion were randomly divided into observation group (45 cases) and control group (45 cases).In all the cases,the pleural effusion was drained by tube thorax.The patients in control group received intrathoracic injection of bleomycin (45-60 mg) +0.9％ sodium chloride + dexamethasone (5 mg) + lidocaine (5 ml) group,the patients in observation group additionally received intrathoracic injection of Addie (50 ml),1 time per week.Four weeks after treatment,the clinical effect,incidence of adverse reactions and Karnofsky performance score (KPS) were evaluated and compared between the two groups.Results After 4 weeks of treatment,the effective rate in observation group reached to 86.7％ (39/ 45),being significantly higher than that in control group 55.6％ (25/45) (P ＜ 0.05);the KPS score and improvement rate of life quality in observation group after treatment were both significantly higher than that in control group [(79 ± 6) scores vs (73 ± 6) scores,75.6％ (34/45) vs 42.2％ (19/45)] (P ＜ 0.05).The incidence of adverse reactions in observation group was significantly lower than that in control group [22.2％ (10/45) vs 68.9％ (31/45)],(P ＜ 0.05).Conclusion Addie injection combined with bleomycin can significantly improve the short-term effect and quality of life with lower incidence of adverse reactions compared with single use of bleomycin in patients of malignant pleural effusion.
