CAJ | 학술논문

目的研究不同剂量玻璃酸钠关节腔内注射辅助关节镜下关节清理术治疗膝骨关节炎患者的临床效果.方法连续选取2013年5月至2014年5月湖北省丹江口市第一医院收治的膝骨关节炎患者共93例,完全随机分为低剂量组、中剂量组、高剂量组,每组31例.低剂量组给予20 mg玻璃酸钠注射液关节腔内注射,中剂量组给予25 mg玻璃酸钠注射液关节腔内注射,高剂量组给予30 mg玻璃酸钠注射液关节腔内注射.对3组患者实施关节镜下关节清理术治疗.结果治疗l周和3个月后3组患者的Lequence评分明显低于治疗前[低剂量组:(5.89±1.34)、(5.24 ±0.28)分比(10.23±2.58)分,中剂量组:(5.19±1.15)、(3.93±0.87)分比(10.28±2.49)分,高剂量组:(5.67±1.23)、(4.96±0.14)分比(10.21 ±2.36)分],Lysholm评分明显高于治疗前[低剂量组:(56.3±15.8)、(74.7±15.4)分比(14.9±2.7)分,中剂量组:(71.9±15.4)、(87.1±14.5)分比(14.3±2.2)分,高剂量组:(58.7±15.4)、(81.2±15.1)分比(14.4±2.6)分](P＜0.05);其中治疗3个月后中剂量组的Lequence评分明显低于低、高剂量组,治疗1周和3个月后Lysholm评分明显高于低、高剂量组;治疗3个月后中剂量组总有效率明显高于低、高剂量组,差异有统计学意义[96.8％ (30/31)比80.6％ (25/31)、83.9％ (26/31)] (P ＜0.05).结论中等剂量的玻璃酸钠注射液关节腔内注射辅助关节镜下关节清理术治疗膝骨关节炎的临床疗效优于低剂量和较高剂量.
목적 연구불동제량파리산납관절강내주사보조관절경하관절청리술치료슬골관절염환자적림상효과.방법 련속선취2013년5월지2014년5월호북성단강구시제일의원수치적슬골관절염환자공93례,완전수궤분위저제량조、중제량조、고제량조,매조31례.저제량조급여20 mg파리산납주사액관절강내주사,중제량조급여25 mg파리산납주사액관절강내주사,고제량조급여30 mg파리산납주사액관절강내주사.대3조환자실시관절경하관절청리술치료.결과 치료l주화3개월후3조환자적Lequence평분명현저우치료전[저제량조:(5.89±1.34)、(5.24 ±0.28)분비(10.23±2.58)분,중제량조:(5.19±1.15)、(3.93±0.87)분비(10.28±2.49)분,고제량조:(5.67±1.23)、(4.96±0.14)분비(10.21 ±2.36)분],Lysholm평분명현고우치료전[저제량조:(56.3±15.8)、(74.7±15.4)분비(14.9±2.7)분,중제량조:(71.9±15.4)、(87.1±14.5)분비(14.3±2.2)분,고제량조:(58.7±15.4)、(81.2±15.1)분비(14.4±2.6)분](P＜0.05);기중치료3개월후중제량조적Lequence평분명현저우저、고제량조,치료1주화3개월후Lysholm평분명현고우저、고제량조;치료3개월후중제량조총유효솔명현고우저、고제량조,차이유통계학의의[96.8％ (30/31)비80.6％ (25/31)、83.9％ (26/31)] (P ＜0.05).결론 중등제량적파리산납주사액관절강내주사보조관절경하관절청리술치료슬골관절염적림상료효우우저제량화교고제량.
Objective To explore the clinical effect of arthroscopic treatment assisted by intraarticular injecting different doses of glass sodium treating knee osteoarthritis.Methods A total of 93 patients with knee osteoarthritis from May 2013 to May 2014 were enrolled and underwent arthroscopic treatment assisted by intraarticular injection of glass sodium.The patients were randomly divided into low dose group (20 mg glass sodium injection),median dose group (25 mg glass sodium injection) and high dose group (30 mg glass sodium injection).One week and 3 months after treatment,the outcomes were evaluated and compared.Results The Lequence and Lysholm score before treatment showed no statistical differences among three groups (P ＞ 0.05).Compared with that before treatment,the Lequence score in the three groups 1 week and 3 months after treatment were all reduced significantly [low dose group:(5.89 ± 1.34),(5.24 ± 0.28) scores vs (10.23 ± 2.58) scores,median dose group:(5.19 ± 1.15),(3.93 ± 0.87) scores vs (10.28 ± 2.49) scores,high dose group:(5.67 ± 1.23),(4.96 ±0.14) scores vs (10.21 ±2.36) scores];the Lysholm score in the three groups were all increased[low dose group:(56.3 ± 15.8),(74.7 ± 15.4) scores vs (14.9 ± 2.7) scores,median dose group:(71.9 ± 15.4),(87.1 ± 14.5) scores vs (14.3 ±2.2) scores,high dose group:(58.7 ± 15.4),(81.2 ± 15.1) scores vs (14.4 ± 2.6) scores] (all P ＜ 0.05).The Lequence score 3 months after treatment and the Lysholm score 1 week and 3 months after treatment in median dose group were more improved compared with those in other two groups (all P ＜ 0.05).Three months after treatment,the total efficacy rate in median dose group was significantly higher compared with that in low dose and high dose group [96.8％ (30/31) vs 80.6％ (25/31),83.9％ (26/31)] (P ＜ 0.05).Conclusion Arthroscopic treatment assisted by intraarticular injection with 25 mg glass sodium is more effective in knee osteoarthritis compared with that with lower and higher doses.