中国医药
中國醫藥
중국의약
CHINA MEDICINE
2015年
5期
732-734
,共3页
羊剑秋%朱红柳%高以红%李超
羊劍鞦%硃紅柳%高以紅%李超
양검추%주홍류%고이홍%리초
带状疱疹%膦甲酸钠%高能红光
帶狀皰疹%膦甲痠鈉%高能紅光
대상포진%련갑산납%고능홍광
Foscarnet%Energetic red%Shingles
目的 观察膦甲酸钠注射液联合高能红光治疗中老年带状疱疹的临床疗效.方法 选取2012年6月至2014年1月江阴市中医院皮肤科收治的85例中老年带状疱疹患者,根据随机数字表法分为观察组(45例)和对照A组(40例),另选取李超收集并发表于《中国麻风皮肤病学》杂志的带状疱疹患者43例作为对照B组.观察组给予膦甲酸钠注射液联合高能红光治疗,对照A组给予喷昔洛韦注射液联合高能红光治疗,对照B组仅给予喷昔洛韦注射液治疗,3组疗程均为10d.比较3组患者的临床疗效及不良反应发生情况.结果 观察组的平均止痛及结痂时间与对照A组相比,差异无统计学意义(P＞0.05),但平均止疱时间比较差异有统计学意义[(2.1±1.3)d比(3.0±1.1)d,P＜0.01].观察组和对照A组的平均止痛、止疱及结痂时间均明显短于对照B组[(3.1±1.3)、(3.2±1.6)d比(4.7±0.8)d,(2.1±1.3)、(3.0±1.1)d比(4.6±0.7)d,(5.9±1.7)、(6.1±0.5)d比(6.8±1.4)d],差异有统计学意义(P＜0.01).观察组与对照A组有效率相比差异无统计学意义(P＞0.05),但观察组和对照A组有效率均高于对照B组[93.3％(42/45)、92.5％ (37/40)比83.7％(36/43)],差异有统计学意义(P＜0.01).观察组有1例发生后遗神经痛,对照A组有4例发生后遗神经痛,对照B组有5例发生后遗神经痛.3组患者不良反应比较差异无统计学意义(P＞0.05).结论 膦甲酸钠注射液联合高能红光治疗带状疱疹可明显提高临床疗效,减少受损神经根的炎性反应,促进恢复.
目的 觀察膦甲痠鈉註射液聯閤高能紅光治療中老年帶狀皰疹的臨床療效.方法 選取2012年6月至2014年1月江陰市中醫院皮膚科收治的85例中老年帶狀皰疹患者,根據隨機數字錶法分為觀察組(45例)和對照A組(40例),另選取李超收集併髮錶于《中國痳風皮膚病學》雜誌的帶狀皰疹患者43例作為對照B組.觀察組給予膦甲痠鈉註射液聯閤高能紅光治療,對照A組給予噴昔洛韋註射液聯閤高能紅光治療,對照B組僅給予噴昔洛韋註射液治療,3組療程均為10d.比較3組患者的臨床療效及不良反應髮生情況.結果 觀察組的平均止痛及結痂時間與對照A組相比,差異無統計學意義(P＞0.05),但平均止皰時間比較差異有統計學意義[(2.1±1.3)d比(3.0±1.1)d,P＜0.01].觀察組和對照A組的平均止痛、止皰及結痂時間均明顯短于對照B組[(3.1±1.3)、(3.2±1.6)d比(4.7±0.8)d,(2.1±1.3)、(3.0±1.1)d比(4.6±0.7)d,(5.9±1.7)、(6.1±0.5)d比(6.8±1.4)d],差異有統計學意義(P＜0.01).觀察組與對照A組有效率相比差異無統計學意義(P＞0.05),但觀察組和對照A組有效率均高于對照B組[93.3％(42/45)、92.5％ (37/40)比83.7％(36/43)],差異有統計學意義(P＜0.01).觀察組有1例髮生後遺神經痛,對照A組有4例髮生後遺神經痛,對照B組有5例髮生後遺神經痛.3組患者不良反應比較差異無統計學意義(P＞0.05).結論 膦甲痠鈉註射液聯閤高能紅光治療帶狀皰疹可明顯提高臨床療效,減少受損神經根的炎性反應,促進恢複.
목적 관찰련갑산납주사액연합고능홍광치료중노년대상포진적림상료효.방법 선취2012년6월지2014년1월강음시중의원피부과수치적85례중노년대상포진환자,근거수궤수자표법분위관찰조(45례)화대조A조(40례),령선취리초수집병발표우《중국마풍피부병학》잡지적대상포진환자43례작위대조B조.관찰조급여련갑산납주사액연합고능홍광치료,대조A조급여분석락위주사액연합고능홍광치료,대조B조부급여분석락위주사액치료,3조료정균위10d.비교3조환자적림상료효급불량반응발생정황.결과 관찰조적평균지통급결가시간여대조A조상비,차이무통계학의의(P＞0.05),단평균지포시간비교차이유통계학의의[(2.1±1.3)d비(3.0±1.1)d,P＜0.01].관찰조화대조A조적평균지통、지포급결가시간균명현단우대조B조[(3.1±1.3)、(3.2±1.6)d비(4.7±0.8)d,(2.1±1.3)、(3.0±1.1)d비(4.6±0.7)d,(5.9±1.7)、(6.1±0.5)d비(6.8±1.4)d],차이유통계학의의(P＜0.01).관찰조여대조A조유효솔상비차이무통계학의의(P＞0.05),단관찰조화대조A조유효솔균고우대조B조[93.3％(42/45)、92.5％ (37/40)비83.7％(36/43)],차이유통계학의의(P＜0.01).관찰조유1례발생후유신경통,대조A조유4례발생후유신경통,대조B조유5례발생후유신경통.3조환자불량반응비교차이무통계학의의(P＞0.05).결론 련갑산납주사액연합고능홍광치료대상포진가명현제고림상료효,감소수손신경근적염성반응,촉진회복.
Objective To investigate the clinical efficacy of high-energy red light therapy combined with foscarnet in treatment of herpes zoster in the middle-aged patients.Methods Eighty five patients with herpes zoster from June 2012 to January 2014 were randomized divided into observation group (45 cases) and control group A (40 cases),in addition,43 patients with herpes zoster in the research published in " China leprosy Dermatology" were set as control group B.The patients received high-energy red light therapy combined with foscarnet injection in observation group,received high-energy red light therapy combined with penciclovir injection in control group A,and received penciclovir injection only in control group B.After 10 days of treatment,the efficiency and adverse reactions were observed and compared among the three groups.Results The time of pain relieving and incrustation in observation group showed no significant differences compared with control group A (P ＞ 0.05),while the herpes stopping time in observation group was shorter than that in control group A [(2.1 ± 1.3) d vs (3.0 ± 1.1)d,P ＜0.01].The time of pain relieving,herpes stopping and incrustation in obserbvation group and control group A were significantly shorter than those in control group B [(3.1 ± 1.3),(3.2 1.6) d vs (4.7 ± 0.8) d;(2.1±1.3),(3.0±1.1) dvs (4.6±0.7) d;(5.9±1.7),(6.1±0.5) dvs (6.8±1.4) d] (P ＜0.01).Efficiency in control group A showed no significant difference compared with that in observation group,both being significantly higher than that in control group B [93.3％ (42/45),92.5％ (37/40) vs 83.7％ (36/43)] (P ＜ 0.01).Postherpetic neuralgia occurred in 1 case of observation group,4 cases of control group A and 5 cases of control group B.There were no significant differences of adverse reactions among the three groups.Conclusion High-energy red light therapy in treatment of herpes zoster in the middle-aged patients combined with foscarnet can significantly improve clinical outcomes and reduce the damage of nerve root inflammation.
