CAJ | 학술논문

目的探讨全血白细胞计数水平与血压水平、高血压患病以及高血压15年累积发生风险的关系.方法入选“中国多省市队列研究”人群中1992和2007年参加心血管疾病危险因素调查的研究对象4 188名.对白细胞计数水平与血压水平和高血压患病的关系进行横断面分析.对基线无高血压的2 954名研究对象进行白细胞计数水平与血压水平变化和高血压发生风险的前瞻性分析,白细胞计数水平与血压水平变化的关联分析采用Spearman秩相关和多重线性回归,白细胞计数水平与高血压发生风险的关联分析采用多因素logistic回归.结果 (1)横断面研究显示,白细胞计数水平与收缩压水平(r =0.208,P＜0.001)和舒张压水平(r=0.154,P＜0.001)均呈正相关.多重线性回归分析显示,白细胞计数每增加1×109/L,收缩压水平增加1.41 mmHg(1 mmHg =0.133 kPa)(95％ CI:1.20 ～ 1.63 mmHg,P＜0.001),舒张压水平增加0.63 mmHg (95％ CI:0.51 ～0.76 mmHg,P＜0.001).多因素logistic回归分析显示白细胞计数每增加1×109/L,高血压患病风险增加15％(OR:1.15,95％ CI:1.12 ～1.19,P＜0.001).(2)在15年的队列随访过程中,47.2％(1 394/2 954)的研究对象发生高血压.Spearman秩相关分析显示,基线白细胞计数水平与收缩压水平增加量(r=0.062,P=0.003)和舒张压水平增加量(r=0.102,P＜0.001)均呈正相关.多重线性回归分析显示,基线白细胞计数每增加1×109/L,收缩压水平增加1.03 mmHg (95％ CI:0.74～1.32 mmHg,P＜0.001),舒张压水平增加0.64 mmHg(95％ CI:0.48 ～0.80 mmHg,P＜0.001).多因素logistic回归分析显示,白细胞计数每增加1×109/L,高血压的发生风险增加9％(OR:1.09,95％ CI:1.06～ 1.13,P＜0.001).结论白细胞计数水平升高与高血压的患病和发生风险均有关,提示慢性炎症可能参与高血压的发生和发展.
목적 탐토전혈백세포계수수평여혈압수평、고혈압환병이급고혈압15년루적발생풍험적관계.방법 입선“중국다성시대렬연구”인군중1992화2007년삼가심혈관질병위험인소조사적연구대상4 188명.대백세포계수수평여혈압수평화고혈압환병적관계진행횡단면분석.대기선무고혈압적2 954명연구대상진행백세포계수수평여혈압수평변화화고혈압발생풍험적전첨성분석,백세포계수수평여혈압수평변화적관련분석채용Spearman질상관화다중선성회귀,백세포계수수평여고혈압발생풍험적관련분석채용다인소logistic회귀.결과 (1)횡단면연구현시,백세포계수수평여수축압수평(r =0.208,P＜0.001)화서장압수평(r=0.154,P＜0.001)균정정상관.다중선성회귀분석현시,백세포계수매증가1×109/L,수축압수평증가1.41 mmHg(1 mmHg =0.133 kPa)(95％ CI:1.20 ～ 1.63 mmHg,P＜0.001),서장압수평증가0.63 mmHg (95％ CI:0.51 ～0.76 mmHg,P＜0.001).다인소logistic회귀분석현시백세포계수매증가1×109/L,고혈압환병풍험증가15％(OR:1.15,95％ CI:1.12 ～1.19,P＜0.001).(2)재15년적대렬수방과정중,47.2％(1 394/2 954)적연구대상발생고혈압.Spearman질상관분석현시,기선백세포계수수평여수축압수평증가량(r=0.062,P=0.003)화서장압수평증가량(r=0.102,P＜0.001)균정정상관.다중선성회귀분석현시,기선백세포계수매증가1×109/L,수축압수평증가1.03 mmHg (95％ CI:0.74～1.32 mmHg,P＜0.001),서장압수평증가0.64 mmHg(95％ CI:0.48 ～0.80 mmHg,P＜0.001).다인소logistic회귀분석현시,백세포계수매증가1×109/L,고혈압적발생풍험증가9％(OR:1.09,95％ CI:1.06～ 1.13,P＜0.001).결론 백세포계수수평승고여고혈압적환병화발생풍험균유관,제시만성염증가능삼여고혈압적발생화발전.
Objective To observe the association between the leukocyte count and blood pressure value and hypertension risk in a Chinese community-based population.Methods A total of 4 188 participants who took part in the baseline examination in 1992 and the follow-up survey in 2007 from the Chinese Multi-Provincial Cohort Study were included in this study.The relationship of leukocyte and blood pressure value and hypertension risk were evaluated by cross-sectional analyses.The prospective association between baseline leukocyte count and blood pressure changes and risk of hypertension were analyzed in 2 954 normotensive individuals at baseline examination.The associations between leukocyte count and blood pressure was evaluated with Spearman's rank correlation analyses and linear regression models,and the associations between leukocyte count and risk of hypertension was evaluated with logistic regression models.Results (1) The cross-sectional study results showed that the correlation coefficient of leukocyte count and systolic blood pressure and diastolic blood pressure was 0.208 and 0.154 (both P ＜ 0.001),respectively.Multiple linear regression analyses showed that every 1 × 109/L increment in leukocyte count was associated with 1.41 mmHg(1 mmHg =0.133 kPa)systolic blood pressure increase (95％ CI:1.20-1.63 mmHg,P ＜0.001) and 0.63 mmHg diastolic blood pressure increase (95％ CI:0.51-0.76 mmHg,P ＜ 0.001).Multivariable logistic regression analyses showed that every 1 × 109/L increment in leukocyte count was associated with a 15％ increased risk of hypertension (OR:1.15,95％ CI:1.12-1.19,P ＜0.001).(2) During 15 years of follow-up,47.2％ (1 394/2 954) normotensive individuals progressed to hypertension.Spearman's rank correlation analyses showed that,the correlation coefficient of leukocyte count and systolic blood pressure change and diastolic blood pressure change was 0.062 (P =0.003) and 0.102 (P＜0.001),respectively.Multiple linear regression analyses showed that every 1 × 109/L increment in baseline leukocyte count was associated with 1.03 mmHg systolic blood pressure increase (95％ CI:0.74-1.32 mmHg,P ＜ 0.001) and 0.64 mmHg diastolic blood pressure increase (95％ CI:0.48-0.80 mmHg,P ＜0.001).Multivariable logistic regression analyses showed that every 1 × 109/L increment in leukocyte count was associated with a 9％ increased risk of incident hypertension (OR:1.09,95％ CI:1.06-1.13,P ＜ 0.001).Conclusion Elevated leukocyte count is associated with increased blood pressure value and hypertension among Chinese community-based population,suggesting that inflammation may participate in the pathogenesis of hypertension.