CAJ | 학술논문

目的：观察热毒宁注射液联合阿奇霉素治疗小儿支原体肺炎的疗效及对炎性介质、免疫功能的影响。方法将我院2011－2012年收治的104例支原体肺炎患儿按随机数字表分为联合组和对照组，每组52例。对照组采取阿奇霉素序贯治疗，联合组采取热毒宁联合阿奇霉素序贯治疗，两组均以14 d为观察节点。比较两组的疗效和X线消失时间，检测两组CRP、IL－6、免疫球蛋白水平并进行比较。结果（1）联合组显效率（88．5％）与对照组（59．6％）比较，差异有统计学意义（χ2＝11．260， P＜0．01）；（2）联合组X线消失时间为（10．23±1．82）d，短于对照组的（13．35±2．21）d（t＝6．022，P＜0．01）；（3）治疗前联合组和对照组比较，炎性介质及免疫功能指标均无统计学差异；治疗后两组比较，CRP、IL－6、IgM、IgG、IgA均有统计学差异（P＜0．01）。结论热毒宁注射液联合阿奇霉素能够协同控制炎性反应，增强免疫功能，提高临床疗效。
목적：관찰열독저주사액연합아기매소치료소인지원체폐염적료효급대염성개질、면역공능적영향。방법장아원2011－2012년수치적104례지원체폐염환인안수궤수자표분위연합조화대조조，매조52례。대조조채취아기매소서관치료，연합조채취열독저연합아기매소서관치료，량조균이14 d위관찰절점。비교량조적료효화X선소실시간，검측량조CRP、IL－6、면역구단백수평병진행비교。결과（1）연합조현효솔（88．5％）여대조조（59．6％）비교，차이유통계학의의（χ2＝11．260， P＜0．01）；（2）연합조X선소실시간위（10．23±1．82）d，단우대조조적（13．35±2．21）d（t＝6．022，P＜0．01）；（3）치료전연합조화대조조비교，염성개질급면역공능지표균무통계학차이；치료후량조비교，CRP、IL－6、IgM、IgG、IgA균유통계학차이（P＜0．01）。결론열독저주사액연합아기매소능구협동공제염성반응，증강면역공능，제고림상료효。
Objective To observe efficacy and influences of Reduning injection combined with azithromycin on inflammatory mediators and immune function in children with mycoplasma pneumonia.Methods 104 children with mycoplasma pneumonia meeting inclusion criteria from 2011 to 2012 in this hospital were randomly divided into 52 cases of study group and control group,52 in each. The control group was given azithromycin sequential therapy,andthe study group was given azithromycin sequential therapy and Redun-ing injection, both groups were treated for 14 days.Symptoms and signs wereobserved before and after treatment, improvements timewas recorded,CRP,IL-6,immunoglobulin levels were detected,clinical efficacy was evaluated.Results (1) The total effectiverates in study group and control group were 88.5%and 59.6%, respectively,with a significant difference(χ2 =11.260,P<0.01).(2) X line disappearing time of the study group was (10.23 ±1.82) d, in the control group was (13.35 ±2.21)d, with significant differ-ence between the two groups (t=6.022, P<0.01).(3) The inflammatory medium and immune function instudy group and control group were not significantly different before treatment;after treatment, the CRP, IL-6, IgM, IgG, IgA of the two groups were signifi-cantly different (all P<0.01).Conclusions Reduning injection combined with azithromycin can synergistically control the inflam-matory response, enhance immune function,andimprove the clinical efficacy.