CAJ | 학술논문

目的：探讨奥氮平和丙戊酸钠治疗双相抑郁的疗效及安全性。方法时长8周的随机双盲对照研究。将69例符合DSM－IV双相抑郁诊断标准的患者随机分为奥氮平组与丙戊酸钠组，在基线和治疗期每周末采用汉密尔顿抑郁量表（HAMD－17）、汉密尔顿焦虑量表（HAMA）、蒙哥马利抑郁量表（MADRS）、贝克－拉范森躁狂评定量表（BRMS）、临床疗效总评量表（CGI－I）和治疗不良反应（TESS）进行评定。结果两组治疗后HAMD、HAMA评分均较治疗前显著降低（P＜0．01），两组间减分率差异无统计学意义，奥氮平组和丙戊酸钠有效率分别为82．86％、82．35％，痊愈率为37．14％、38．24％，有效率及痊愈率差异均无统计学意义，但奥氮平起效更为迅速。结论奥氮平可有效治疗双相抑郁。
목적：탐토오담평화병무산납치료쌍상억욱적료효급안전성。방법시장8주적수궤쌍맹대조연구。장69례부합DSM－IV쌍상억욱진단표준적환자수궤분위오담평조여병무산납조，재기선화치료기매주말채용한밀이돈억욱량표（HAMD－17）、한밀이돈초필량표（HAMA）、몽가마리억욱량표（MADRS）、패극－랍범삼조광평정량표（BRMS）、림상료효총평량표（CGI－I）화치료불량반응（TESS）진행평정。결과량조치료후HAMD、HAMA평분균교치료전현저강저（P＜0．01），량조간감분솔차이무통계학의의，오담평조화병무산납유효솔분별위82．86％、82．35％，전유솔위37．14％、38．24％，유효솔급전유솔차이균무통계학의의，단오담평기효경위신속。결론오담평가유효치료쌍상억욱。
Objective To assess the efficacy and safety of olanzapine andsodium valproate monotherapy for bipolar depres-sion.Methods Seventy-one patients who met DSM-IV criteria for bipolar depression were randomly assigned to treatment with olanza-pine ( n=35) or sodium valproate( n=36) in a double-blind parallel-group study design.The treatment duration was 8weeks.Planned assessments included Bech-Rafaelsen Mania Rating Scale( BRMs) , Clinical Global Impressions-Improvement Scale ( CGI-I) , Hamilton Depression Scale ( HAMD) , Hamilton Anxiety Scale ( HAMA) , and Treatment Emergent Symptom Scale( TESS) .Results Improve-ments in MADRS total score, CGI-I, and HAMD in the olanzapine group were not significantly different relative to those in the sodium valproate during the 8-week follow-up period (P<0.01, P=0.0017, P=0.007, and P<0.01, respectively).The rate of response (82.86%and 55.88%,respectively) and remission(37.14% and 26.47%,respectively) in olanzapine group and sodium valproate group,showed no statistically significant difference.But,olanzapine-treated group had a more rapid onset of effect than sodium val-proate-treated patients in score of HAMA,with significant difference between two groups(P<0.01).Conclusions Olanzapine mono-therapy is effective in the treatment of bipolar depression.