CAJ | 학술논문

目的：探讨口服美沙拉嗪联合康复新液灌肠治疗溃疡性结肠炎（ ulcerative colitis ，UC）的临床疗效及其对凝血指标的影响。方法选择80例符合入选标准的UC患者，根据治疗方案按数字表格随机分为观察组和对照组，每组40例。对照组给予口服美沙拉嗪肠溶片，观察组在对照组的基础上联合应用康复新液灌肠治疗。疗程结束后，比较两组患者临床疗效及其凝血指标变化情况；随访6个月，观察比较复发率。结果观察组治疗总有效率为95．0％，对照组为80．0％（ P＜0．05）；凝血指标：治疗后观察组PLT（189．1±94．5）、FIB（2．4±0．2）降低，PT（13．9±1．6）、MPV（9．8±0．5）升高，与对照组相应指标（212．6±97．2；3．3±0．3；10．8±1．2；7．4±0．6）比较，差异有统计学意义（ P＜0．05）。随访6个月，观察组复发率为7．5％，明显低于对照组（27．5％），差异有统计学意义（P＜0．05）。结论口服美沙拉嗪联合康复新液灌肠治疗UC可明显缓解临床症状，提高治疗效果，并能改善凝血指标，减少复发。
목적：탐토구복미사랍진연합강복신액관장치료궤양성결장염（ ulcerative colitis ，UC）적림상료효급기대응혈지표적영향。방법선택80례부합입선표준적UC환자，근거치료방안안수자표격수궤분위관찰조화대조조，매조40례。대조조급여구복미사랍진장용편，관찰조재대조조적기출상연합응용강복신액관장치료。료정결속후，비교량조환자림상료효급기응혈지표변화정황；수방6개월，관찰비교복발솔。결과관찰조치료총유효솔위95．0％，대조조위80．0％（ P＜0．05）；응혈지표：치료후관찰조PLT（189．1±94．5）、FIB（2．4±0．2）강저，PT（13．9±1．6）、MPV（9．8±0．5）승고，여대조조상응지표（212．6±97．2；3．3±0．3；10．8±1．2；7．4±0．6）비교，차이유통계학의의（ P＜0．05）。수방6개월，관찰조복발솔위7．5％，명현저우대조조（27．5％），차이유통계학의의（P＜0．05）。결론구복미사랍진연합강복신액관장치료UC가명현완해림상증상，제고치료효과，병능개선응혈지표，감소복발。
Objective To investigate the clinical effect of oral administration of mesalazine in combination with Kangfuxin so-lution enema in the treatment of ulcerative colitis ( UC) and its effects on coagulation parameters.Methods 80 patients with UC meeting the inclusion criteria were randomly divided into observation group (n=40) and the control group(n=40) according to the treatment plan in digital form.The control group was treated with oral administration of mesalazine, while the observation group was treated in combination with Kangfuxin solution enema on the basis of the control group.After the treatment, the two groups of patients were compared in clinical efficacy and coagulation parameters index changes.And they were followed up for 6 months, the recurrence rate was observed and compared.Results The observation group had a total effective rate of 95.0%, which was higher than that of 80.0%in the control group (P<0.05).In coagulation parameters indexes : the count of platelets (PLT)(189.1 ±94.5)and con-centration of fibrinogen (FIB)(2.4 ±0.2)were lower in the observation group after treatment, while the prothrombin time (PT)(13.9 ±1.6) and mean platelet volume (MPV)(9.8 ±0.5)were higher (P<0.05), and the corresponding indexes(212.6 ±97.2;3.3 ± 0.3;10.8 ±1.2;7.4 ±0.6)compared with those in the control group showed statistical significance (P<0.05).After six-month fol-low-up, it was shown that the observation group had a lower recurrence rate of 7.5% than that of 27.5% in the control group ( P<0.05).Conclusions Oral administration of mesalazine in combination with Kangfuxin solution enema in the treatment of UC can ob-viously relieve the clinical symptoms, improve the effect of treatment and coagulation parameters indexes, reduce the recurrence rate;it is worth of further clinical research.