CAJ | 학술논문

第10号染色体缺失的磷酸酶和张力蛋白同源基因（PTEN）可通过信号转导通路调控细胞周期，影响细胞的生长发育和程序性死亡，参与调节细胞的迁移和黏附，维护免疫系统的稳定。在口腔鳞状细胞癌（OSCC）的发生发展过程中，可能并不存在PTEN基因的突变和缺失，却可能与PTEN?mRNA表达水平降低有一定的关系。PTEN蛋白在健康黏膜和口腔黏膜下纤维性变（OSF）到OSCC的不同组织学类型标本中表达逐渐下降，是OSF的发病机制和恶性转化机制中的重要分子事件。PTEN蛋白与OSCC的组织学和生物学行为有关，可作为其未来的预后指标。在多种肿瘤中，各种调控所导致PTEN蛋白的低表达，影响PTEN蛋白参与的多级信号转导，导致其在协调细胞周期进展，控制程序性细胞死亡及细胞黏附，抑制癌细胞转移和增殖等方面难以发挥预期的作用。
제10호염색체결실적린산매화장력단백동원기인（PTEN）가통과신호전도통로조공세포주기，영향세포적생장발육화정서성사망，삼여조절세포적천이화점부，유호면역계통적은정。재구강린상세포암（OSCC）적발생발전과정중，가능병불존재PTEN기인적돌변화결실，각가능여PTEN?mRNA표체수평강저유일정적관계。PTEN단백재건강점막화구강점막하섬유성변（OSF）도OSCC적불동조직학류형표본중표체축점하강，시OSF적발병궤제화악성전화궤제중적중요분자사건。PTEN단백여OSCC적조직학화생물학행위유관，가작위기미래적예후지표。재다충종류중，각충조공소도치PTEN단백적저표체，영향PTEN단백삼여적다급신호전도，도치기재협조세포주기진전，공제정서성세포사망급세포점부，억제암세포전이화증식등방면난이발휘예기적작용。
Phosphatase?and?tensin?homolog?gene?deleted?on?chromosome?10(PTEN)?plays?an?essential?role?not?only?in?cell?cycle?regulation,?limiting?cell?growth,?and?proliferation,?but?also?in?cell?migration?regulation,?adhesion,?and?maintenance?of?the?stability?of?the?immune?system?through?the?signal?transduction?pathway.?The?PTEN?gene?may?not?undergo?mutation?and?deletion?during?the?development?of?oral?squamous?cell?carcinoma(OSCC)?but?may?be?specifically?related?to?the?reduction?of?the?PTEN?mRNA?expression?level.?The?PTEN?protein?exhibits?decreased?expression?in?different?histological?types?of?specimens,?ranging?from?healthy?oral?mucosa?and?oral?submucous?fibrosis(OSF)?to?OSCC.?This?event?is?important?in?the?pathogenesis?and?malignant?transformation?mechanism?of?OSF.?The?expression?of?the?PTEN?protein?is?related?to?the?histological?and?biological?behavior?of?OSCC?and?can?be?used?as?a?prognostic?indicator?of?OSCC.?The?low?expression?of?the?PTEN?protein?caused?by?different?factors?may?cause?difficulty?in?performing?its?role?on?coordination?of?cell?cycle,?control?of?programmed?cell?death?and?cell?adhesion,?inhibition?of?metastasis?and?proliferation?of?cancer?cells.