CAJ | 학술논문

牙龈卟啉单胞菌细胞表面的多种抗原可诱导机体产生保护性免疫应答，阻止牙龈卟啉单胞菌定植和感染，因此选择合适的牙龈卟啉单胞菌有效免疫原作为疫苗候选抗原来防治牙周炎具有重要的研究价值。牙龈卟啉单胞菌细胞膜上的菌毛蛋白、牙龈蛋白、血凝蛋白、外膜蛋白、被膜蛋白和热休克蛋白等多种表面抗原，皆有可能成为牙龈卟啉单胞菌相关牙周炎疫苗有效免疫原。牙周炎疫苗研究常用的免疫途径有腺体免疫、黏膜免疫、皮下接种和肌肉注射等，学者们普遍认为，黏膜免疫应该成为牙周炎疫苗免疫的主要方式。另外，牙周炎疫苗中使用佐剂可刺激机体产生免疫应答，增强抗原免疫原性。在未来的牙周炎疫苗研究中，应该结合牙龈卟啉单胞菌的多种特异性抗原找到各血清型牙龈卟啉单胞菌共同的抗原决定簇，结合其他牙周致病菌的有效免疫原及选择最有效的免疫途径和使用抗原呈递和佐剂系统。
아간계람단포균세포표면적다충항원가유도궤체산생보호성면역응답，조지아간계람단포균정식화감염，인차선택합괄적아간계람단포균유효면역원작위역묘후선항원래방치아주염구유중요적연구개치。아간계람단포균세포막상적균모단백、아간단백、혈응단백、외막단백、피막단백화열휴극단백등다충표면항원，개유가능성위아간계람단포균상관아주염역묘유효면역원。아주염역묘연구상용적면역도경유선체면역、점막면역、피하접충화기육주사등，학자문보편인위，점막면역응해성위아주염역묘면역적주요방식。령외，아주염역묘중사용좌제가자격궤체산생면역응답，증강항원면역원성。재미래적아주염역묘연구중，응해결합아간계람단포균적다충특이성항원조도각혈청형아간계람단포균공동적항원결정족，결합기타아주치병균적유효면역원급선택최유효적면역도경화사용항원정체화좌제계통。
Multiple?antigens?on?the?surface?of?Porphyromonas gingivalis(P.gingivalis)can?induce?the?body?to?confer?protective?immunity?and?prevent?bacterial?colonization?and?infection.?Therefore,?selection?of?a?suitable?and?effective?immunogen?of?P.gingivalis?is?important?to?prevent?periodontitis.?Multiple?antigens?of?P.gingivalis?include?fimbria,?gingipain,?hemagglutinin,?outer?membrane?protein,?capsule,?and?heat?shock?protein.?These?antigens?can?be?effective?immunogens?of?a?vaccine?against?periodontitis.?Gland?immune,?mucosal?immune,?subcutaneous?injection,?and?muscle?injection?are?common?methods?for?administering?the?vaccine.?Mucosal?immune?is?generally?accepted?as?the?main?administration?method?of?the?periodontitis?vaccine.?The?use?of?adjuvants?in?the?periodontitis?vaccine?can?also?stimulate?immune?responses?and?enhance?antigen?immunogenicity.?Future?research?on?vaccines?against?periodontitis?should?combine?the?vaccine?with?various?antigens?of?P.gingivalis.?Through?this?method,?scholars?can?determine?the?common?antigens?of?each?serotype,?associate?the?effective?immunogens?of?other?periodontal?pathogens,?and?select?the?most?effective?immune?pathway?and?antigen-presenting?adjuvants.