CAJ | 학술논문

在牙周炎这一慢性炎症反应过程中，补体不仅可以调解机体防御反应，保护宿主，还可直接作用于免疫细胞或通过调控信号转导通路，协助病原菌进一步感染和破坏牙周组织，最终导致免疫病理性的损伤反应。在免疫炎症反应中，补体不仅可刺激白细胞分泌白细胞介素、肿瘤坏死因子和粒细胞-巨噬细胞集落刺激因子，调节辅助性T细胞和巨噬细胞，促进细胞免疫和T细胞依赖的抗体分泌，增强免疫效应的调节，提高机体免疫力；亦可引起的炎症反应可对组织造成损伤，引起牙周炎。以补体受体拮抗剂干扰补体受体-Toll样受体信号转导通路，有利于机体清除病原菌，达到防治牙周炎的目的。理解补体在牙周炎发生发展中的作用，可为牙周炎治疗探索新途径。
재아주염저일만성염증반응과정중，보체불부가이조해궤체방어반응，보호숙주，환가직접작용우면역세포혹통과조공신호전도통로，협조병원균진일보감염화파배아주조직，최종도치면역병이성적손상반응。재면역염증반응중，보체불부가자격백세포분비백세포개소、종류배사인자화립세포-거서세포집락자격인자，조절보조성T세포화거서세포，촉진세포면역화T세포의뢰적항체분비，증강면역효응적조절，제고궤체면역력；역가인기적염증반응가대조직조성손상，인기아주염。이보체수체길항제간우보체수체-Toll양수체신호전도통로，유리우궤체청제병원균，체도방치아주염적목적。리해보체재아주염발생발전중적작용，가위아주염치료탐색신도경。
The?complement?system?mediates?the?body’s?defense?reactions?to?protect?the?host?against?periodontal?chronic?inflammatory?diseases.?This?system?assists?pathogens?to?exacerbate?pathological?and?destructive?inflammation?by?directly?affecting?immune?cells?or?via?crosstalk?and?by?regulating?other?host?signaling?pathways.?The?complement?system?induces?secretion?of?interleukin,?tumor?necrosis?factor,?and?granulocyte-macrophage?colony-stimulating?factor?during?immune?inflammation.?Secretion?is?stimulated?by?activating?leukocytes,?regulating?helper?T?cells?and?macrophages,?and?promoting?cell?immune?and?T?cell-dependent?antibody?secretion,?thus?enhancing?the?regulation?of?immune?effect?and?improving?the?body’s?immunity.?Furthermore,?the?complement?system?produces?inflammation?that?exacerbates?tissue?damage?and?triggers?periodontitis.?The?antagonists?of?the?complement?receptor?can?significantly?clean?pathogens?and?prevent?periodontitis?by?interfering?the?signaling?crosstalk?between?the?complement?receptor?and?Toll-like?receptors.?Therefore,?elucidating?the?mechanism?of?the?complement?system?in?periodontitis?can?provide?novel?targets?for?periodontitis?therapeutics.