CAJ | 학술논문

1011易位甲基胞嘧啶双加氧酶（TET）-1是发挥DNA去甲基化作用重要的蛋白质之一，始见于急性髓系白血病相关的染色体易位t（10；11）（q22；q23）的白血病患者，其C端为双加氧酶区，是TET-1的主要催化功能结构域，可将5-甲基胞嘧啶（5-mC）氧化为5-羟甲基胞嘧啶，经主动或被动去甲基化实现DNA去甲基化。TET-1通过参与DNA去甲基化调节基因表达，在胚胎发育、体细胞重编程、肿瘤发生、神经细胞发生发育等过程发挥作用，在成体细胞中参与调控细胞分化与增殖。TET-1蛋白及其介导的5-mC羟甲基化过程深化了人们对DNA碱基修饰多样性及复杂性的认识，其在干细胞增殖与分化和肿瘤发生等过程中的功能研究，为诸多生理现象和疾病发生发展作了新的诠释。
1011역위갑기포밀정쌍가양매（TET）-1시발휘DNA거갑기화작용중요적단백질지일，시견우급성수계백혈병상관적염색체역위t（10；11）（q22；q23）적백혈병환자，기C단위쌍가양매구，시TET-1적주요최화공능결구역，가장5-갑기포밀정（5-mC）양화위5-간갑기포밀정，경주동혹피동거갑기화실현DNA거갑기화。TET-1통과삼여DNA거갑기화조절기인표체，재배태발육、체세포중편정、종류발생、신경세포발생발육등과정발휘작용，재성체세포중삼여조공세포분화여증식。TET-1단백급기개도적5-mC간갑기화과정심화료인문대DNA감기수식다양성급복잡성적인식，기재간세포증식여분화화종류발생등과정중적공능연구，위제다생리현상화질병발생발전작료신적전석。
Ten-eleven?translocation?methyl?cytosine?dioxygenase(TET)-1,?one?of?the?important?protein?in?DNA?demethylation?pathway,?is?found?in?acute?myeloid?leukemia?and?is?associated?with?chromosomal?translocation?t(10;11)?(q22;q23)?in?patients?with?leukemia.?The?C-terminal?dioxygenase?district?is?the?main?catalytic?functional?domain?of?TET-1,?can?oxidized?five?methylcytosine(5-mC)?into?5-hydroxymethyl?cytosine.?TET-1?plays?a?role?in?embryogenesis,?somatic?cell?reprogramming,?tumorigenesis,?development?of?nerve?cells,?and?regulation?of?cell?differentiation?and?proliferation?in?adult?cells?by?participating?in?demethylation?and?regulation?of?DNA?gene?expression.?The?hydroxy?methylation?of?5-mC?in?the?TET-1?protein?has?elucidated?the?diversity?and?complexity?of?DNA?gene?expression.?This?mechanism?has?also?been?used?in?stem?cell?proliferation,?differentiation,?and?tumorigenesis?for?functional?studies?of?many?physiological?phenomena?to?provide?novel?interpretation?for?the?occurrence?and?development?of?diseases.