国际口腔医学杂志
國際口腔醫學雜誌
국제구강의학잡지
JOURNAL OF INTERNATIONAL STOMATOLOGY
2015年
3期
318-322
,共5页
口腔扁平苔藓%免疫%炎症%低氧诱导因子-1α
口腔扁平苔蘚%免疫%炎癥%低氧誘導因子-1α
구강편평태선%면역%염증%저양유도인자-1α
oral lichen planus%immunity%inflammation%hypoxia-inducible factor-1α
低氧诱导因子(HIF)-1是机体低氧反应中的重要转录因子,在免疫炎症反应中参与调控免疫细胞分化、促进黏附、影响细胞代谢、诱导新生血管形成、调控细胞增殖与凋亡等。近年研究表明,HIF-1α在口腔扁平苔藓的发生发展过程中可能发挥着重要作用,本文将从HIF-1的结构、功能及调控,免疫炎症反应中HIF-1α的表达, HIF-1α在口腔扁平苔藓发生、发展中的作用等方面作一综述。
低氧誘導因子(HIF)-1是機體低氧反應中的重要轉錄因子,在免疫炎癥反應中參與調控免疫細胞分化、促進黏附、影響細胞代謝、誘導新生血管形成、調控細胞增殖與凋亡等。近年研究錶明,HIF-1α在口腔扁平苔蘚的髮生髮展過程中可能髮揮著重要作用,本文將從HIF-1的結構、功能及調控,免疫炎癥反應中HIF-1α的錶達, HIF-1α在口腔扁平苔蘚髮生、髮展中的作用等方麵作一綜述。
저양유도인자(HIF)-1시궤체저양반응중적중요전록인자,재면역염증반응중삼여조공면역세포분화、촉진점부、영향세포대사、유도신생혈관형성、조공세포증식여조망등。근년연구표명,HIF-1α재구강편평태선적발생발전과정중가능발휘착중요작용,본문장종HIF-1적결구、공능급조공,면역염증반응중HIF-1α적표체, HIF-1α재구강편평태선발생、발전중적작용등방면작일종술。
Hypoxia-inducible?factor(HIF)-1?is?an?important?transcription?factor?in?cellular?adaptation?to?hypoxic?conditions?is?involved?in?regulating?immune?cell?differentiation,?promoting?the?adhesion?and?influence?the?formation?of?cell?metabolism,?inducing?new?blood?vessels,?and?regulating?cell?proliferation?and?apoptosis,?among?others.?In?recent?years, studies have shown that HIF-1α may play an important role in the pathogenesis of oral lichen planus. This article reviewed?the?research?progress?onHIF-1inthe?following?aspects:?the?structure,?function,?and?regulation?of?HIF-1,?immune?inflammatory response in the expression of HIF-1α, and the role of HIF-1α in the occurrence and development of oral lichen?planus.