CAJ | 학술논문

目的：???观察口腔黏膜下纤维性变（OSF）并存白斑（OLK）患者的临床表现以及病理特征，探讨其上皮异常增生程度与纤维性变严重程度的相关性。方法整理74例OSF并存OLK患者的临床病理资料并进行分析。结果74例OSF并存OLK患者多见于中青年男性，均有咀嚼槟榔史，以20~49岁年龄段发病率较高，临床上同时具有OSF、OLK的临床症状和体征。病理表现为上皮细胞间隙增宽；基底膜增厚、不规则；胶原纤维水肿，变性。结论 OSF并存OLK患者的上皮异常增生程度与纤维性变严重程度无显著相关性；OSF并存OLK并非两种疾病的单纯叠加，而具有其特征性的表现。
목적：???관찰구강점막하섬유성변（OSF）병존백반（OLK）환자적림상표현이급병리특정，탐토기상피이상증생정도여섬유성변엄중정도적상관성。방법정리74례OSF병존OLK환자적림상병리자료병진행분석。결과74례OSF병존OLK환자다견우중청년남성，균유저작빈랑사，이20~49세년령단발병솔교고，림상상동시구유OSF、OLK적림상증상화체정。병리표현위상피세포간극증관；기저막증후、불규칙；효원섬유수종，변성。결론 OSF병존OLK환자적상피이상증생정도여섬유성변엄중정도무현저상관성；OSF병존OLK병비량충질병적단순첩가，이구유기특정성적표현。
Objective???The?objective?of?this?study?is?to?observe?the?clinical?and?pathological?characteristics?of?oral?submucous?fibrosis(OSF)?coexisting?with?oral?leukoplakia(OLK)?to?analyze?the?relationship?between?the?degree?of?epithelial?hyperplasia?and?the?severity?of?fibrosis.?Methods???The?clinical?and?pathological?data?of?74?patients?with?OSF?coexisting?with?OLK?were?collected?and?reviewed.?Results??Seventy-four?patients?with?OSF?coexisting?with?OLK?were?mainly?young?and?middle-aged?male?patients.?All?had?the?habit?of?chewing?betel?quid,?and?all?exhibited?symptoms?of?OSF?and?OLK,?but?higher?prevalence?is?observed?in?age?range?of?20?to?49.?Pathological?features?include?widened?epithelial?cell?gap,?thickened?basement?membrane,?and?degenerated?collagen?fibers.?Conclusion???No?relationship?was?found?between?the?degree?of?epithelial?hyperplasia?and?the?severity?of?fibrosis?in?patients?with?OSF?coexisting?with?OLK.?OSF?coexisting?with?OLK?is?not?simply?a?combination?of?two?diseases;?rather,?the?combination?of?which?has?peculiar?features.