CAJ | 학술논문

目的：探讨阿奇霉素治疗活动期强直性脊柱炎的临床疗效。方法：入选活动期强直性脊柱炎64例，治疗组（n ＝32）予阿奇霉素治疗，对照组（n ＝32）予非甾体消炎药和免疫抑制剂常规治疗，共观察24周，以疾病活动性指标BASDAI、CRP和ESR作为疗效评价指标。结果：2组活动性指标在治疗第4～20周较治疗前下降（P ＜0．05），在第20～24周有上升趋势，逐渐恢复至治疗前水平。在治疗0～16周观察期间，治疗组活动性指标基本维持在正常水平以下，对照组高于正常水平，差异具有统计学意义（P ＜0．05）。结论：阿奇霉素有助于较长时间控制疾病活动，减少疾病复发，药物安全性良好，对临床治疗有一定的指导意义。
목적：탐토아기매소치료활동기강직성척주염적림상료효。방법：입선활동기강직성척주염64례，치료조（n ＝32）여아기매소치료，대조조（n ＝32）여비치체소염약화면역억제제상규치료，공관찰24주，이질병활동성지표BASDAI、CRP화ESR작위료효평개지표。결과：2조활동성지표재치료제4～20주교치료전하강（P ＜0．05），재제20～24주유상승추세，축점회복지치료전수평。재치료0～16주관찰기간，치료조활동성지표기본유지재정상수평이하，대조조고우정상수평，차이구유통계학의의（P ＜0．05）。결론：아기매소유조우교장시간공제질병활동，감소질병복발，약물안전성량호，대림상치료유일정적지도의의。
Objective To investigate the clinical effect of azithromycin on ankylosing spondylitis (AS). Methods Sixty-four AS patients with active disease were enrolled in this study. Among them, thirty-two AS patients (treatment group)received Azithromycin treatment at a dose of 0.5 g once a day for a period of 5~7 days , and another thirty-two patients receiving conventional treatment served as control (control group). BASDAI, CRP and ESR served as the disease activity evaluation index. Results Activity indexes in two groups of in the first 4~ 20 weeks of the treatment were decreased compared with those before the treatment (P < 0.05), while a rise was found in the 20 ~ 24 week and activity indexes gradually returned to pretreatment levels. At 0 ~ 16 weeks , the disease activity index of treatment group was below normal levels but that of control group was higher than the normal level with significant difference (P < 0.05). Conclusion The treatment of Azithromycin can control the disease activity of AS in the long term, which would be a new proposal in AS treatment.