CAJ | 학술논문

目的：探讨法舒地尔对早期糖尿病肾病患者氧化应激的影响。方法：将48例早期糖尿病肾病患者随机分为硫辛酸组、法舒地尔组。所有患者严格控制血糖，治疗2周后观察血清胱抑素C（Cysc）、尿微量白蛋白（mALB）、尿8－羟基脱氧鸟苷（8-OHdG）变化。结果：与治疗前相比，治疗后硫辛酸组和法舒地尔组尿mALB、血清Cysc 和尿8-OHdG 水平均明显下降；治疗前和治疗后两组之间血清 Cysc、尿 mALB 和8-OHdG水平比较，差异无显著性。结论：法舒地尔对早期糖尿病患者有肾脏保护作用，其保护作用机制可能与降低8-OHdG的水平、减轻氧化应激有关。
목적：탐토법서지이대조기당뇨병신병환자양화응격적영향。방법：장48례조기당뇨병신병환자수궤분위류신산조、법서지이조。소유환자엄격공제혈당，치료2주후관찰혈청광억소C（Cysc）、뇨미량백단백（mALB）、뇨8－간기탈양조감（8-OHdG）변화。결과：여치료전상비，치료후류신산조화법서지이조뇨mALB、혈청Cysc 화뇨8-OHdG 수평균명현하강；치료전화치료후량조지간혈청 Cysc、뇨 mALB 화8-OHdG수평비교，차이무현저성。결론：법서지이대조기당뇨병환자유신장보호작용，기보호작용궤제가능여강저8-OHdG적수평、감경양화응격유관。
Objective To investigate the influence of Fasudil on oxidative stress in patients with early-stage diabetic nephropathy. Methods 48 patients with earl-stage diabetic nephopathy were randomly divided into control group treated with Alpha-lipoic acid and treametn group with Fasudil. All patients were under strict control of blood glucose. Changes in the levels of serum cysc, urinal mALB and 8-OHdG were observed after two weeks treatment were compared between the two groups. Results Compared to pre-treatment, the content of serum cysc, urinal mALB and 8-OHdG were significantly decreased in both groups after treatment. There was no significant difference in the content of urine mAlb , CTGF and MCP-1 between the two groups before and after treatment (P > 0.05). Conclusion Fasudil may protect kidney through a mechanism by which the level of 8-OHdG in kidney is decreased and oxidative stress is alleviated.