CAJ | 학술논문

泪液是眼表的一种成分复杂的体液,可能含有数千种蛋白质及其他分子,研究已证实这些成分的改变在眼病的发生和发展中具有重要作用.泪液标本相对容易获取,可用于眼表疾病及其他眼科疾病或系统性疾病的研究,也可用于生物标志物的鉴定,因此是临床诊疗和新药研发的重要依据.跟踪和了解泪液蛋白质组学的研究技术和泪液蛋白质组学的研究进展有助于相关研究的深入开展,眼科医师应密切关注眼表疾病泪液蛋白质组分的变化及其临床意义,关注泪液蛋白质组学未来的发展方向,以指导相关眼病的诊疗和研究.
루액시안표적일충성분복잡적체액,가능함유수천충단백질급기타분자,연구이증실저사성분적개변재안병적발생화발전중구유중요작용.루액표본상대용역획취,가용우안표질병급기타안과질병혹계통성질병적연구,야가용우생물표지물적감정,인차시림상진료화신약연발적중요의거.근종화료해루액단백질조학적연구기술화루액단백질조학적연구진전유조우상관연구적심입개전,안과의사응밀절관주안표질병루액단백질조분적변화급기림상의의,관주루액단백질조학미래적발전방향,이지도상관안병적진료화연구.
Tear fluid is a complex body fluid,which may contain thousands of protein/peptides and other molecules.Studies have determined that the changes in the chemical compositions of tears play an important role in some diseases and their progression.Tear fluid is a useful and easily accessible source for understanding ocular surface diseases,other eye diseases,and systemic diseases.It can also be used for identification of biomarkers for clinical applications and pharmaceutical development.Therefore,quantitative proteomic analysis of tears may provide very important information for diagnosis and treatment of eye diseases or the development of new drugs.Knowledge of the current proteomic technologies for tear analysis is helpful for conducting studies.In addition,ophthalmologists should pay close attentions to the association between tear proteomic changes and eye diseases,recent advances in tear proteomics and their applications in studying ocular surface diseases and conditions.