国际医药卫生导报
國際醫藥衛生導報
국제의약위생도보
INTERNATIONAL MEDICINE & HEALTH GUIDANCE NEWS
2015年
9期
1217-1220
,共4页
刘凌云%曾勉%左万里%康丽玫
劉凌雲%曾勉%左萬裏%康麗玫
류릉운%증면%좌만리%강려매
慢性阻塞性肺疾病%NT-proBNP%肺动脉高压%肺心病
慢性阻塞性肺疾病%NT-proBNP%肺動脈高壓%肺心病
만성조새성폐질병%NT-proBNP%폐동맥고압%폐심병
Chronic obstructive pulmonary disease%Brain natriuretic peptide%Pulmonary hypertension%Corpulmonale
目的 探讨血浆NT-proBNP检测在彩超检查无肺动脉高压或肺心病稳定期慢性阻塞性肺疾病(COPD)中的意义.方法 选60例COPD患者和30例健康对照者,并进行血浆BNP检测、超声心动图检查、动脉血气分析和肺功能测定.对血浆BNP水平高的COPD患者和血浆BNP水平低的COPD患者进行2年的急性加重期情况的随访比较.结果 稳定期COPD患者血浆NT-ProBNP(680.6±54.78) pg/ml显著高于健康对照组[(120.4± 15.65) pg/ml] (P＜0.05).血浆NT-ProBNP水平和射血分数之间呈显著负相关(r=-0.56,P＜0.05)和肺动脉收缩压呈显著正相关(r=0.68,P＜0.05).在2年的急性加重情况随访期间,以NT-proBNP≥500 pg/n1为截点值,血浆NT-ProBNP水平高的COPD患者从开始随访到初次的COPD急性加重的时间[(6.25±1.23)月]较血浆NT-ProBNP水平低的患者加重的时间[(10.13±2.08)月]显著缩短(P＜0.05),且急性加重的次数(3.35±0.25)显著增加(P＜0.05).结论 血浆BNP是一种非侵入性生物标志物,可以作为COPD潜在肺动脉高压及左室功能障碍的一个筛选参数,并可作为稳定期患者急性加重的预测因素.
目的 探討血漿NT-proBNP檢測在綵超檢查無肺動脈高壓或肺心病穩定期慢性阻塞性肺疾病(COPD)中的意義.方法 選60例COPD患者和30例健康對照者,併進行血漿BNP檢測、超聲心動圖檢查、動脈血氣分析和肺功能測定.對血漿BNP水平高的COPD患者和血漿BNP水平低的COPD患者進行2年的急性加重期情況的隨訪比較.結果 穩定期COPD患者血漿NT-ProBNP(680.6±54.78) pg/ml顯著高于健康對照組[(120.4± 15.65) pg/ml] (P＜0.05).血漿NT-ProBNP水平和射血分數之間呈顯著負相關(r=-0.56,P＜0.05)和肺動脈收縮壓呈顯著正相關(r=0.68,P＜0.05).在2年的急性加重情況隨訪期間,以NT-proBNP≥500 pg/n1為截點值,血漿NT-ProBNP水平高的COPD患者從開始隨訪到初次的COPD急性加重的時間[(6.25±1.23)月]較血漿NT-ProBNP水平低的患者加重的時間[(10.13±2.08)月]顯著縮短(P＜0.05),且急性加重的次數(3.35±0.25)顯著增加(P＜0.05).結論 血漿BNP是一種非侵入性生物標誌物,可以作為COPD潛在肺動脈高壓及左室功能障礙的一箇篩選參數,併可作為穩定期患者急性加重的預測因素.
목적 탐토혈장NT-proBNP검측재채초검사무폐동맥고압혹폐심병은정기만성조새성폐질병(COPD)중적의의.방법 선60례COPD환자화30례건강대조자,병진행혈장BNP검측、초성심동도검사、동맥혈기분석화폐공능측정.대혈장BNP수평고적COPD환자화혈장BNP수평저적COPD환자진행2년적급성가중기정황적수방비교.결과 은정기COPD환자혈장NT-ProBNP(680.6±54.78) pg/ml현저고우건강대조조[(120.4± 15.65) pg/ml] (P＜0.05).혈장NT-ProBNP수평화사혈분수지간정현저부상관(r=-0.56,P＜0.05)화폐동맥수축압정현저정상관(r=0.68,P＜0.05).재2년적급성가중정황수방기간,이NT-proBNP≥500 pg/n1위절점치,혈장NT-ProBNP수평고적COPD환자종개시수방도초차적COPD급성가중적시간[(6.25±1.23)월]교혈장NT-ProBNP수평저적환자가중적시간[(10.13±2.08)월]현저축단(P＜0.05),차급성가중적차수(3.35±0.25)현저증가(P＜0.05).결론 혈장BNP시일충비침입성생물표지물,가이작위COPD잠재폐동맥고압급좌실공능장애적일개사선삼수,병가작위은정기환자급성가중적예측인소.
Objective To investigate the significance of detecting the plasma level of brain natriuretic peptide (BNP) in color ultrasound checking COPD patients in stable stage without pulmonary hypertension or corpulmonale.Methods 60 patients with COPD and 30 healthy subjects were chosen.Their plasma level of BNP,echocardiography,arterial blood gas analysis,and spirometry were detected.The status of acute exacerbation of the COPD patients with high or low plasma BNP levels were compared and followed up for 2 years.Results The plasma level of NT-ProBNP of the COPD patients in stable stage was (680.6±54.78) pg/ml,which was significantly higher than that of the normal subjects (120.4±15.65) pg/ml (P＜0.05).Plasma level of BNP negatively correlated with ejection fraction (r=-0.56,P＜0.05) and positively correlated with pulmonary artery systolic pressure (r=0.68,P＜0.05).During the 2 years' followup of acute exacerbation status,with plasma level of NT-ProBNP ＞500 pg/ml as the cut-off,the time from the beginning of the follow-up to the first acute exacerbation of COPD was shorter and the times of acute exacerbation was more in the patients with high than low plasma level of NT-ProBNP [(6.25±1.23) months vs.(10.13±2.08) months and (3.35±0.25) vs.(1.12±0.18),P＜0.05].Conclusions Plasma BNP is a noninvasive biomarker that can be used as a screening parameter for latent PH and left ventricular dysfunction and also as a predictor of exacerbation in stable COPD.
