中华实验眼科杂志
中華實驗眼科雜誌
중화실험안과잡지
CHINESE JOURNAL OF EXPERIMENTAL OPHTHALMOLOGY
2015年
5期
461-465
,共5页
陈吉利%陈镔瑶%周兰%杨剑玲%郑策
陳吉利%陳鑌瑤%週蘭%楊劍玲%鄭策
진길리%진빈요%주란%양검령%정책
视网膜%神经纤维层%体层摄影术,光学相干性/方法%年龄%吸光度%吸光系数
視網膜%神經纖維層%體層攝影術,光學相榦性/方法%年齡%吸光度%吸光繫數
시망막%신경섬유층%체층섭영술,광학상간성/방법%년령%흡광도%흡광계수
Retina%Nerve fiber layer%Tomography,optical coherence/method%Age%Absorbance%Attenuate coefficient
背景 Cirrus光学相干断层扫描(OCT)测量视网膜神经纤维层(RNFL)已广泛用于眼科临床,基于OCT的光学特征,其在某些眼科疾病的检测中可以弥补空间测量的不足,但目前相关研究较少. 目的 观察正常人RNFL的OCT光学特征,研究其与年龄的关系. 方法 纳入2011年6月至2012年6月在上海市北医院体检的健康者406人,年龄40 ～ 83岁,平均58.6岁,均纳入一侧眼统计.采用Cirrus OCT的5线扫描模式测量黄斑区RNFL,使用图像处理软件分析RNFL的光学特征,包括吸光度(A)值和吸光系数,比较不同年龄层次不同性别间的测量结果,对RNFL的A值和吸光系数与受试者年龄的关系进行分析. 结果 共纳入353名受试者,受试者RNFL厚度、A值和吸光系数的平均值分别为(35.1±4.4) μm、121.6±5.3和2.06±0.25.RNFL厚度、A值与受试者年龄均呈线性负相关(r=-0.487、-0.571,均P＜0.01),回归方程分别为Y=-0.17 X+45.23、Y=-0.24 X+135.82,而RNFL吸光系数则与受试者年龄呈正相关(rs=0.368,P＜0.01),一元回归方程为Y=0.01 X+1.63.受检眼RNFL厚度和RNFL A值与OCT信号强度间均呈微弱正相关(rs=0.128,P=0.016;rs=0.284,P＜0.01),而RNFL吸光系数与OCT信号强度间无明显相关关系(rs=-0.053,P=0.319).结论 正常人RNFL的OCT光学特征参数受年龄的影响,在研究RNFL的光学特征变化时,应考虑年龄因素.
揹景 Cirrus光學相榦斷層掃描(OCT)測量視網膜神經纖維層(RNFL)已廣汎用于眼科臨床,基于OCT的光學特徵,其在某些眼科疾病的檢測中可以瀰補空間測量的不足,但目前相關研究較少. 目的 觀察正常人RNFL的OCT光學特徵,研究其與年齡的關繫. 方法 納入2011年6月至2012年6月在上海市北醫院體檢的健康者406人,年齡40 ～ 83歲,平均58.6歲,均納入一側眼統計.採用Cirrus OCT的5線掃描模式測量黃斑區RNFL,使用圖像處理軟件分析RNFL的光學特徵,包括吸光度(A)值和吸光繫數,比較不同年齡層次不同性彆間的測量結果,對RNFL的A值和吸光繫數與受試者年齡的關繫進行分析. 結果 共納入353名受試者,受試者RNFL厚度、A值和吸光繫數的平均值分彆為(35.1±4.4) μm、121.6±5.3和2.06±0.25.RNFL厚度、A值與受試者年齡均呈線性負相關(r=-0.487、-0.571,均P＜0.01),迴歸方程分彆為Y=-0.17 X+45.23、Y=-0.24 X+135.82,而RNFL吸光繫數則與受試者年齡呈正相關(rs=0.368,P＜0.01),一元迴歸方程為Y=0.01 X+1.63.受檢眼RNFL厚度和RNFL A值與OCT信號彊度間均呈微弱正相關(rs=0.128,P=0.016;rs=0.284,P＜0.01),而RNFL吸光繫數與OCT信號彊度間無明顯相關關繫(rs=-0.053,P=0.319).結論 正常人RNFL的OCT光學特徵參數受年齡的影響,在研究RNFL的光學特徵變化時,應攷慮年齡因素.
배경 Cirrus광학상간단층소묘(OCT)측량시망막신경섬유층(RNFL)이엄범용우안과림상,기우OCT적광학특정,기재모사안과질병적검측중가이미보공간측량적불족,단목전상관연구교소. 목적 관찰정상인RNFL적OCT광학특정,연구기여년령적관계. 방법 납입2011년6월지2012년6월재상해시북의원체검적건강자406인,년령40 ～ 83세,평균58.6세,균납입일측안통계.채용Cirrus OCT적5선소묘모식측량황반구RNFL,사용도상처리연건분석RNFL적광학특정,포괄흡광도(A)치화흡광계수,비교불동년령층차불동성별간적측량결과,대RNFL적A치화흡광계수여수시자년령적관계진행분석. 결과 공납입353명수시자,수시자RNFL후도、A치화흡광계수적평균치분별위(35.1±4.4) μm、121.6±5.3화2.06±0.25.RNFL후도、A치여수시자년령균정선성부상관(r=-0.487、-0.571,균P＜0.01),회귀방정분별위Y=-0.17 X+45.23、Y=-0.24 X+135.82,이RNFL흡광계수칙여수시자년령정정상관(rs=0.368,P＜0.01),일원회귀방정위Y=0.01 X+1.63.수검안RNFL후도화RNFL A치여OCT신호강도간균정미약정상관(rs=0.128,P=0.016;rs=0.284,P＜0.01),이RNFL흡광계수여OCT신호강도간무명현상관관계(rs=-0.053,P=0.319).결론 정상인RNFL적OCT광학특정삼수수년령적영향,재연구RNFL적광학특정변화시,응고필년령인소.
Background The measurement of retinal nerve fiber layer (RNFL) by Cirrus optical coherence tomography (OCT) has been applied widely in ophthalmology.However,previous assessment of RNFL is based on spatial measurement,while the evaluation based on optical characteristics of OCT can offset the shortcomings of spatial measurement in some eye diseases.Objective This study was to analyze the optical characters of RNFL measured by OCT and its correlation with age in healthy Chinese individuals.Methods Four hundred and six normal healthy subjects were collected in Shanghai Shibei Hospital from June 2011 to June 2012,with the age of 40-83 years old.Macular RNFL was unilateral imaged using a Cirrus OCT device with 5 line raster macular scan mode under the approval of Ethic Committee of Shanghai Shibei Hospital and informed consent of subjects.A customized software was used to measure RNFL optical characters,including absorbance (A value) and attenuate coefficient.The difference of the measured parameters in different genders was compared.The correlations between RNFL optical characters and age were analyzed by linear regression analysis.Results The data of 353 eyes were included in the final outcomes.The RNFL thickness,A value and attenuate coefficient were (35.1 ±4.4) μm,121.6 ±5.3 and 2.06 ±0.25,respectively.RNFL thickness and A value showed significantly negative correlations with age (r=-0.487,-0.571,both at P＜0.01) with the regression equation Y=-0.17 X+45.23 and Y=-0.24 X+ 135.82,while a positive correlation was found between the attenuate coefficient and age (r=0.368,P＜0.01) with the regression equation Y=0.01 X+1.63.RNFL thickness and A value showed weaker positive correlations with OCT signal intensity (rs =0.128,P =0.016;rs =0.284,P＜0.01),but no remarked correlation was seen between the attenuate coefficient and OCT signal intensity (rs =-0.053,P=0.319).Conclusions Age of subjects affects the parameters of OCT optical characteristics in normal populaition.Age-related RNFL change in optical characters of OCT should be considered before concluding optical parameters.
