中华实验眼科杂志
中華實驗眼科雜誌
중화실험안과잡지
CHINESE JOURNAL OF EXPERIMENTAL OPHTHALMOLOGY
2015年
5期
478-480
,共3页
血小板反应蛋白-1%转化生长因子-β%角膜/创伤修复
血小闆反應蛋白-1%轉化生長因子-β%角膜/創傷脩複
혈소판반응단백-1%전화생장인자-β%각막/창상수복
Thrombospondin-1%Transforming growth factor-1β%Corneal/wound healing
血小板反应蛋白-1 (THBS-1)是一种细胞外基质蛋白,其在角膜创伤修复中发挥的作用是近年来国内外研究的热点.研究发现THBS-1可通过激活转化生长因子-β1(TGF-β1)来促进细胞增生、细胞外基质形成、诱导细胞移行,从而在上皮基底膜、基质层和内皮修复中起重要作用,这将为临床上治疗各种原因引起的角膜创伤开辟新的途径.本文就THBS-1的来源及结构、生物学功能及其在角膜创伤修复过程中所起的作用进行综述.
血小闆反應蛋白-1 (THBS-1)是一種細胞外基質蛋白,其在角膜創傷脩複中髮揮的作用是近年來國內外研究的熱點.研究髮現THBS-1可通過激活轉化生長因子-β1(TGF-β1)來促進細胞增生、細胞外基質形成、誘導細胞移行,從而在上皮基底膜、基質層和內皮脩複中起重要作用,這將為臨床上治療各種原因引起的角膜創傷開闢新的途徑.本文就THBS-1的來源及結構、生物學功能及其在角膜創傷脩複過程中所起的作用進行綜述.
혈소판반응단백-1 (THBS-1)시일충세포외기질단백,기재각막창상수복중발휘적작용시근년래국내외연구적열점.연구발현THBS-1가통과격활전화생장인자-β1(TGF-β1)래촉진세포증생、세포외기질형성、유도세포이행,종이재상피기저막、기질층화내피수복중기중요작용,저장위림상상치료각충원인인기적각막창상개벽신적도경.본문취THBS-1적래원급결구、생물학공능급기재각막창상수복과정중소기적작용진행종술.
Thrombospondin-1 (THBS-1),a kind of extracellular matrix proteins,whose biological action played an important role in corneal wound healing has became a research highlight.The currently research findings showed that THBS-1 could promote the healing of epithelium,stroma and endothelium through activating the transforming growth factor-β1 (TGF-β1) which can accelerate cell proliferation,promote stroma forming and inducing cell migration.It is worthful in clinical treatment of all kinds of corneal wound healing.Now we summarized the research developments which have been acquired in the field recently in this article.
