CAJ | 학술논문

从5-甲氧基苯胺出发，探索出了用Sandmeyer法两步合成目标分子5-甲氧基靛红的合成方法，找到了合成目标分子的最佳条件：以水为溶剂，在90℃条件下，5-甲氧基苯胺与水合氯醛，盐酸羟胺反应3.5 h，得到对甲氧基异亚硝基乙酰苯胺，产率95%.在92℃，浓H2SO4（75%）条件下环合,经水解后得到5-甲氧基靛红，产率为88%.使用该方法合成5-甲氧基靛红，反应操作简便高效.
종5-갑양기분알출발，탐색출료용Sandmeyer법량보합성목표분자5-갑양기전홍적합성방법，조도료합성목표분자적최가조건：이수위용제，재90℃조건하，5-갑양기분알여수합록철，염산간알반응3.5 h，득도대갑양기이아초기을선분알，산솔95%.재92℃，농H2SO4（75%）조건하배합,경수해후득도5-갑양기전홍，산솔위88%.사용해방법합성5-갑양기전홍，반응조작간편고효.
Two-step synthesis of 5-MeO isatin using 5-MeO aniline with the method called Sandmeyer has been ex?plored. The optimum reaction condition for the synthesis of 2-(hydroxyimino)-N-(4-methoxyphenyl)acetamide is in water, three components 5-MeO aniline and chloral hydrate and hydroxylamine hydrochloride as bases have been reacting together at 90℃for 3.5 hours,leading to the desired product in 95%yield. After acid hydrolysis with concentrated sulfuric acid(75%) at 92℃, 5-MeO isatin will be gained with 88%of yield. Therefore,with this highly efficient method, 5-MeO isatin can be prepared in a large scale in laboratory.