CAJ | 학술논문

目的：探讨培美曲塞化疗前是否需要提前5～7 d 补充叶酸预处理。方法：对比分析2010年1月至2013年12月就诊于南京市第一医院呼吸科接受培美曲塞治疗的晚期非鳞状非小细胞肺癌70例，根据培美曲塞首次化疗时补充叶酸时间分为提前补充叶酸组（35例）和未提前补充叶酸组（35例）。观察并分析两组患者化疗后不良反应及疗效的差异。结果：提前补充叶酸组无完全缓解（CR）病例，部分缓解（PR）22例，有效率为63％；非提前补充叶酸组无CR 病例，PR 23例，有效率为63％，两组患者有效率的比较差异无统计学意义。两组之间血液性及非血液性毒性差异亦无显著性。结论：培美曲塞首次化疗前可能不必提前1周进行补充叶酸治疗。
목적：탐토배미곡새화료전시부수요제전5～7 d 보충협산예처리。방법：대비분석2010년1월지2013년12월취진우남경시제일의원호흡과접수배미곡새치료적만기비린상비소세포폐암70례，근거배미곡새수차화료시보충협산시간분위제전보충협산조（35례）화미제전보충협산조（35례）。관찰병분석량조환자화료후불량반응급료효적차이。결과：제전보충협산조무완전완해（CR）병례，부분완해（PR）22례，유효솔위63％；비제전보충협산조무CR 병례，PR 23례，유효솔위63％，량조환자유효솔적비교차이무통계학의의。량조지간혈액성급비혈액성독성차이역무현저성。결론：배미곡새수차화료전가능불필제전1주진행보충협산치료。
Objective To explore whether 5 to -7-day of folic acid supplementation prior to pemetrexed therapy is needed. Methods We retrospectively evaluate the outcomes of non-small cell lung cancer patients received less than the advised folic acid premedication. Seventy patients with Ⅲ-Ⅳ NSCLC were randomly divided into two groups: patients who initiated vitamin supplementation on 7 days before the first dose of pemetrexed (group A) and patients who initiated vitamin supplementation on the day of the first dose of pemetrexed (group B). Results In group A and group B, CR 0 and 0, PR 10 and 8, the response rates of 28.6% and 22.9% were observed, respectively. There was no statistically significant differences between these two groups. No significant differences were observed in the incidence of hematologic and non-hematologic toxicities. Conclusions The initiation of pemetrexed-based chemotherapy does not need to accommodate a vitamin supplementation schedule.