CAJ | 학술논문

目的：测定盐酸鲁拉西酮在甲醇、乙醇、异丙醇和环己烷中的溶解度，为化合物制备和晶型筛选以及片剂制备工艺研究提供依据。方法采用HPLC法测定盐酸鲁拉西酮的峰面积，按外标法进行浓度计算；对实验结果分别用多项式经验方程、理想溶液模型以及Apelblat方程模型进行了关联。结果盐酸鲁拉西酮在4种溶剂中的溶解度大小为：甲醇>乙醇>异丙醇>环己烷；在4种溶剂中的溶解度均随温度升高而增加；在3种模型中采用多项式经验方程和Apelblat 方程关联的效果均较好。结论实验得到的溶解度数据及关联结果对化合物制备和晶型筛选以及片剂制备工艺研究具有较大的指导意义。
목적：측정염산로랍서동재갑순、을순、이병순화배기완중적용해도，위화합물제비화정형사선이급편제제비공예연구제공의거。방법채용HPLC법측정염산로랍서동적봉면적，안외표법진행농도계산；대실험결과분별용다항식경험방정、이상용액모형이급Apelblat방정모형진행료관련。결과염산로랍서동재4충용제중적용해도대소위：갑순>을순>이병순>배기완；재4충용제중적용해도균수온도승고이증가；재3충모형중채용다항식경험방정화Apelblat 방정관련적효과균교호。결론실험득도적용해도수거급관련결과대화합물제비화정형사선이급편제제비공예연구구유교대적지도의의。
Objective To determine the solubilities of Lurasidone·HCl in methanol, ethanol, <br> isopropanol and cyclohexane at temperatures from (288.15 to 323.65) K under atmospheric pressure.Method The concentrations of Lurasidone·HCl in different solvents were analyzed by HPLC method, and the experimental results were associatied by Polynomial equation, Ideal solution and Apelblat equation. Results The solubilities of Lurasidone·HCl in different solvents were in the following order: methanol>ethanol>isopropanol>cyclohexan e, and were increasing with temperatures in methanol, ethanol, isopropanol and cyclohexane. The solubility results showed good agreement with Polynomial equation and Apelblat equation.Conclusions The solubility data and related experimental results had significance for the preparation of polymorph screening and tablets process.